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alfa-Aminoalkylphosphonates Induced Apoptosis in Human Tumor Cell Lines

Drąg M.

Polish Journal of Chemistry

2005

Vol. 79 / nr 3

593-602

Evaluation of the in vitro activity of the 1-amino-3-phenylpropanephosphonic acid and diphenyl 1-(N-benzyloxycarbonylamino)-1-(4-amidinophenyl)methanephosphonate hydrochloride toward acute, human Jurkat and A549 cell lines revealed that these compounds are potent inducers of apoptosis. Their potency to inhibit proliferation of tested tumor lines is similar to bestatin, a well-known inhibitor of aminopeptidases and strong inducer of apoptosis in the number of cancer cell. In this paper preliminary experimental details as well as the possible mechanism of action of alfa-aminoalkylphosphonates will be discussed.