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Epithelial cell damage due to airway reopening – an experimental investigation

Kuraszkiewicz B.

Biocybernetics and Biomedical Engineering

2007

Vol. 27, no. 4

49-58

Airway collapse and reopening due to mechanical ventilation exerts mechanical stress on airway walls and injures surfactant - compromised lungs. The reopening of a collapsed airway was modeled experimentally by progression of a semi-infinite bubble in a narrow fluid-occluded channel. The extent of injury caused by bubble progression to pulmonary epithelial cells lining the channel was evaluated. Counter intuitively, cell damage increased with decreasing opening velocity. The presence of pulmonary surfactant, Infasurf, completely abated the injury. These results support the hypotheses that mechanical stresses associated with airway reopening injure pulmonary epithelial cells and that pulmonary surfactant protects the epithelium from this injury.