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Assay of the thermally stable, insensitive, high explosive 1,3,5-triamino-2,4,6-trinitrobenzene (TATB)

Nandi A. K., Thirupathi N., Mandal A. K., Pandey P. K.

Central European Journal of Energetic Materials

2014

Vol. 11, no. 2

295--305

An aqueous titration method is described to assay the insensitive, high explosive 1,3,5-triamino-2,4,6-trinitrobenzene (TATB). TATB is initially quantitatively converted to the weak acid 1,3,5-trihydroxy-2,4,6-trinitrobenzene (THTNB) by base catalysed hydrolysis. Subsequently THTNB is assayed by acidbase titration. TATB samples obtained from regular batch operations are assayed by this method, and the results are compared with those obtained by the total amino functional group estimation method using a modified Kjeldhal apparatus. The method is simple and has good accuracy and precision.

Assay of the Insensitive High Explosive 3-Nitro-1,2,4-triazol-5-one (NTO) by Acid-Base Titration

Nandi A. K., Singh S. K., Kunjir G. M., Singh J., Mandal A. K., Pandey R. K.

Central European Journal of Energetic Materials

2013

Vol. 10, no. 1

113--122

The insensitive high explosive 3-nitro-1,2,4-triazol-5-one (NTO) is a weak acid (pKa 3.76) due to the labile N–H bond. The weakly acidic character of this compound is exploited for its assay by aqueous acid-base titration. The NTO sample was dissolved in water and the resultant solution was titrated against 0.07 N NaOH solution using phenolphthalein as indicator. Regular batch samples were assayed by this method and the results were compared with those obtained by the HPLC method. The aqueous acid-base titration method was found to be suitable for the quality control of the product.

Acid-base titrimetric determination of ketoconazole and miconazole in micellar media

Shamsipur M., Jalali F.

Chemia Analityczna

2002

Vol. 47, No. 6

905-911

A simple and accurate pH-metric method is described for the determination of two sparingly soluble in water antifungal drugs: ketoconazole and miconazole. Cetyltrimethylammo-nium bromide and sodium dodecylsulfate micelles have been used to solubilize these compounds. The application of the proposed method to the analysis of pharmaceutical preparations of the related species gave satisfactory results. Simplicity and the absence of harmful organic solvents in this method makes it possible to be used in routine analyses.

Opisano prostą i dokładną metodę pehametryczną oznaczania dwóch trudno rozpuszczalnych w wodzie leków przecigrzybicznych: ketokonazolu i mykonazolu. Do poprawy rozpuszczalności użyto bromku cetylotrimetyloamoniowego, oraz dodecylosiarczanu sodowego. Opracowaną metodę zastosowano z powodzeniem w analizie preparatów farmaceutycznych zawierających wyżej wspomniane związki. Metoda nadaje się do zastosowania w analizach rutynowych ze względu na prostotę i nieobecność szkodliwych rozpuszczalników organicznych.