Wyniki wyszukiwania - BazTech

Ograniczanie wyników

2 Polish Journal of Chemistry

Znaleziono wyników: 2

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: acetoacetanilide

Sortuj według:

Ogranicz wyniki do:

Studies on the Interaction of Transition Metal Complexes of the Schiff Base Derived from Anthranilic Acid and Acetoacetanilide with DNA

Raman N., Rajasekaran K.

Polish Journal of Chemistry

2007

Vol. 81, nr 2

149-159

Four neutral complexes of Cu(II), Ni(II), Co(II) and Zn(II) have been prepared with a new tridentate Schiff base (HL) derived from anthranilic acid and acetoacetanilide. The analytical data show that themetal to ligand ratio is 1:2. The structural features have been determined from IR, UV-Vis, 1H-NMR, ESR and mass spectral data. All the complexes exhibit octahedral geometry around the central metal ion. Their low electrical conductance values support their neutral nature. The magnetic moment data provide evidence for the monomeric nature of the complexes. Absorption experiments have been carried out on the interaction of the complexes with calf thymus DNA (CT-DNA). The results suggest that all the complexes can bind to CT-DNA by intercalation between chromophore and DNAbase pairs. An electrochemical study of the copper complex reveals that it prefers to bind to DNA in the Cu(II) rather than the Cu(I) oxidation state. The nucleolytic cleavage activity of all the complexes was examined on CT-DNA by using a gel electrophoresis experiment in the presence and absence of oxidant, H2O2. In the absence of the oxidant, a less discernible DNAcleavage was observed, whereas in the presence of the oxidant, all complexes showed enhanced nuclease activity.

1-(N,N-Dimethylamino)-2-(N-phenylcarbamoyl)-1-buten-3-one as a Building Block for the Synthesis of Heterocyclic Compounds

Elmaati T., Said S., Elenein N. A., Sofan M., Khodeir N.

Polish Journal of Chemistry

2002

Vol. 76 / nr 7

945-952

Acetoacetanilide 1 reacted withDMF-DMAto give the enaminone 2. Compound 2, when treated with hydrazines gives the pyrazoles 4a and 4b respectively, and with pyrazole derivatives 5a and 5b the pyrazolopyrimidines 7. On the other hand, in reaction of 2 with benzimidazole and benzimidazole-2-acetonitrile, the pyrimidobenzimidazole 14 and the pyridobenzimidazole 17 were formed. 2 reacts with hippuric acid in boiling acetic anhydride to afford the pyridine 20. In the reaction of 2 with malononitrile, cyanoacetamide or malononitrile dimer compounds 21, 22 and 24 were formed. Compound 22 was further reacted with arylidenemalononitriles to give the benzopyridine derivatives 28. Pyridone 22 treated with S-DMF mixture gives thienopyridine 29, while refluxed with DMFDMA yielded the pyridopyridine 30.