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Analogues of Arginine Vasopressin (AVP) Modified in the N-Thermal Part of the Molecule with N-Benzylglycine

Jastrzębska B., Derdowska I., Kuncarowa P., Slaninova J., Lammek B., B. Olejniczak B., Zabrocki J.

Polish Journal of Chemistry

2002

Vol. 76 / nr 6

823-830

The synthesis and some pharmacological properties of five new analogues of arginine vasopressin (AVP) substituted with N-benzylglycine are described. All new peptides were tested for pressor and uterotonic activity. The results obtained imply that the structural change studied is in general incompatible with interaction of the analogues withV1A and OT receptors, however, in combination with suitable additional changes, may be of value in the design of new antagonists of these receptors.