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Anticancer activity of some new series of 2-(substituted)amino-1,3-thiazole derivatives

Bakare Safyah B.

Polish Journal of Chemical Technology

2019

Vol. 21, nr 3

19--25

A series of thiazole derivatives were synthesized and structurally elucidated by IR, 1H NMR, 13C NMR, mass and elemental analyses. The prepared compounds were screened for their cytotoxic activity against Leukemia HL-60 cell line. Compound 4b was considered as the most promising antitumor candidate among the tested compounds. Mechanism of action of compound 4b evaluated by flow cytometric assay revealed cell cycle arrest at G2/M phase and pre-G1 apoptosis. The ratio of apoptosis was also determined. Moreover, compound 4b increased the concentration of caspase 3 by 4 fold more than untreated control.

Synthesis of Novel Triazolo[4,3-a]Quinoxaline Darivatives Containing Pyridinyl and Thiazole Nucleous

Kathrotiya H. G., Naliapara Y. T.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 52

63--73

On pursuing research about [1,2,4] triazolo [4,3-a] quinoxaline, in this paper we report a small library of novel class of [1,2,4] triazolo [4,3-a] quinoxaline derivatives containing pyridinyl thiazole moiety. Particularly valuable features of this method include high yield, broad substrate scope, shorter reaction time and straightforward procedure. The structures of new compounds have been characterized on the basis of elemental analysis, FT-IR, 1H NMR, 13C NMR, and mass spectral data.