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A Monte Carlo investigation of the dose distribution for new I-125 Low Dose Rate brachytherapy source in water and in different media

Fardi Zeinab, Taherparvar Payvand

Polish Journal of Medical Physics and Engineering

2019

Vol. 25, Iss. 1

15--22

Permanent and temporary implantation of I-125 brachytherapy sources has become an official method for the treatment of different cancers. In this technique, it is essential to determine dose distribution around the brachytherapy source to choose the optimal treatment plan. In this study, the dosimetric parameters for a new interstitial brachytherapy source I-125 (IrSeed-125) were calculated with GATE/GEANT4 Monte Carlo code. Dose rate constant, radial dose function and 2D anisotropy function were calculated inside a water phantom (based on the recommendations of TG-43U1 protocol), and inside several tissue phantoms around the IrSeed-125 capsule. Acquired results were compared with MCNP simulation and experimental data. The dose rate constant of IrSeed-125 in the water phantom was about 1.038 cGy·h−1U−1 that shows good consistency with the experimental data. The radial dose function at 0.5, 0.9, 1.8, 3 and 7 cm radial distances were obtained as 1.095, 1.019, 0.826, 0.605, and 0.188, respectively. The results of the IrSeed-125 is not only in good agreement with those calculated by other simulation with MCNP code but also are closer to the experimental results. Discrepancies in the estimation of dose around IrSeed-125 capsule in the muscle and fat tissue phantoms are greater than the breast and lung phantoms in comparison with the water phantom. Results show that GATE/GEANT4 Monte Carlo code produces accurate results for dosimetric parameters of the IrSeed-125 LDR brachytherapy source with choosing the appropriate physics list. There are some differences in the dose calculation in the tissue phantoms in comparison with water phantom, especially in long distances from the source center, which may cause errors in the estimation of dose around brachytherapy sources that are not taken account by the TG43-U1 formalism.

Determination of the geometry function for a brachytherapy seed, comparing MCNP results with TG-43U1 analytical approximations

Raisali G., Ghonchehnazi M. G., Shokrani P., Sadeghi M.

Nukleonika

2008

Vol. 53, No. 2

45-49

Geometry function is the only dosimetry parameter of a brachytherapy source seed, introduced in TG-43U1 protocol which is determined using calculational methods rather than physical measurement. In order to evaluate the accuracy of point and line source approximations, for calculation of the geometry function, the MCNP computer code has been used for a typical brachytherapy seed and the results have been compared. The MCNP has been used to simulate the geometry and activity distribution of a Pd-103 seed in order to calculate the geometry function for various angles and distances from the source. The comparison of results shows that at distances close to the source, the values predicted with different methods are not in agreement. The difference between the MCNP calculations and line approximation for small angles from ? = 0 to 15° is about 27% at 0.25 cm from the seed center. This difference is so much higher for point source approximation (up to a factor of 3) even up to distances of 0.5 cm from the source. As ? increases, the difference between MCNP and approximate methods is reduced. Therefore, for small distances from brachytherapy seeds, it is recommended to calculate the geometry function using more detailed methods instead of point and linear source approximations. This will provide more accurate results for other TG-43U1 dosimetry parameters such as radial dose function or anisotropy function which for some points are calculated via interpolation or extrapolation of the available discrete dosimetry data.