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Studies on Schiff Base Complexes of Salicylaldehyde with Sulphamethoxazole and Their Antimicrobial Activities

Sheela C., Gomathi A., Ravichandran S., Tharmaraj P.

Polish Journal of Chemistry

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2006

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Vol. 80, nr 11

1781-1787

EN

New neutral Schiff base complexes of Cu(II), Co(II), Ni(II) and Zn(II) derived from salicylaldehyde and sulphamethoxazole have been synthesized. The structural features of the complexes have been confirmed by microanalytical data, IR, UV-Vis and EPR techniques. The electronic absorption spectra and magnetic susceptibility measurement values of the complexes indicate square-planar geometry for copper and nickel and tetrahedral for cobalt and zinc complexes. The neutral nature of the complexes follows from their low molar conductance values. The EPR spectrum of copper complex in DMSO at 300 K and 77 K was recorded and its salient features are reported. The antimicrobial activity of the complexes has been extensively studied on microorganisms such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa by well-diffusion technique using DMSO as a solvent. The values of zone of inhibition were found out at 37 graduateC for a period of 24 h. It has been found that all the studied complexes have higher activity than the free ligand and the standard.

2

New Neutral Schiff Base and Its Metal Complexes Derived from Mannich Base, N-(1-Morpholinobenzyl)acetamideRaman, N.

Raman N., Ravichandran S.

Polish Journal of Chemistry

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2005

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Vol. 79 / nr 7

1107-1114

EN

New neutral Schiff base complexes of Cu(II), Co(II), Ni(II) and Zn(II) derived from 4-aminoantipyrine and N-(1-morpholinobenzyl)acetamide (Mannich base) have been synthesized. The structural features of the complexes have been confirmed by microanalytical data, IR, UV-Vis., NMR, EPR, and CV techniques. Electronic absorption spectra of the complexes indicate an octahedral geometry around the metal ion. Their magnetic susceptibility measurements and low conductance data provide evidence for the monomeric and neutral natures of the complexes respectively. The electrochemical behaviour, the anodic and cathodic potential and the number of electrons transferred were calculated using cyclic voltammogram. The X-band EPR spectrum of copper complex in DMSO at 300 K and 77 K was recorded and its salient features are reported. The antimicrobial activity of the ligand and its complexes has been extensively studied on microorganisms such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and the fungi Aspergillus niger and Rhizoctonia bataicola by well-diffusion technique using DMF as solvent. It has been found that all the complexes have higher activity than the free ligand and the standard.

3

Studies on Schiff Base Complexes of beta-Diketones/Beta-Ketoesters with 2,4-Dinitrophenylhydrazone and Their Antimicrobial Activities

Raman N., Ravichandran S.

Polish Journal of Chemistry

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2004

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Vol.78 /nr 11-12

2005-2012

EN

2,4-Dinitrophenylhydrazone derivatives of Cu(II), Co(II) and Ni(II) complexes have been synthesized. The structural features of the complexes have been confirmed by microanalytical data, IR,UV-Vis, EPR, CV, TGAand powderXRDtechniques. The electronic absorption spectra and magnetic susceptibility indicate a square-planar geometry for copper and tetrahedral for cobalt and nickel complexes. The neutral nature of the complexes is characterized by their low molar conductance. The cyclic voltammogram of copper complex in DMSO solution shows a quasi-reversible peak. The EPR spectrum of copper complex in DMSO at 300 K and 77 K was recorded and its salient features are reported. The antimicrobial activity of the complexes has been extensively studied on microorganisms such as Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa and the fungi Aspergillus niger and Rhizoctonia bataicola by well-diffusion technique using pyridine as solvent. The values of zone of inhibition were found out at 37°C for a period of 24 h. It has been found that all the product complexes have a higher activity than the parent complexes and the standard.