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UPLC-MS/MS analysis of SZJ-1207 in mouse plasma and brain and application in pharmacokinetic studies

Qi Dake, Sun Yingying, Hu Bingying, An Hai, Lin Haiyang, Fang Jinjun, Wei Yang

Acta Chromatographica

2024

Vol. 36, no. 2

99--105

SZJ-1207 is an antidepressant natural product with a steroidal structure extracted from Stephanotis mucronata. It is a novel antidepressant candidate molecule and all its pharmacokinetic properties have not been reported. In this pharmacokinetic study in mice following oral administration, an accurate and sensitive UPLC-MS/MS method was established and evaluated to measure SZJ-1207 concentrations in mouse plasma and brain samples. The results provide information regarding the pharmacokinetics of SZJ-1207 as a potential antidepressant.