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1 TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk

1 2014

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Protein-protein interaction and coarse grained simulation study of glioblastoma multiforme reveals novel pathways of Gpr17

Gnanavel M., Yli-Harja O., Kandhavelu M.

TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk

2014

Vol. 18, No 4

321--325

Studies of receptor mediated signaling networks in neuronal cells pro vide a unique opportunity to uncover the basis of many diseases. Receptor signaling c ascades proceed from the cell surface, where extra cellular factors interact with their specific receptors e.g. G-Protein Coupled Receptors ( GPR ). Recent studies have shown that the activation or suppression of GPR 17 in diseased neuronal cells has potential impact in altering the tumor con ditions. We identified many hundred times expressions of GPR 17 in Glioblastoma Multiforme ( GBM ) from the RNA -Seq data. We also observed many other genes having similar expression patt erns with GPR 17, indicating possible connections of this receptor with diverse gen e products. We performed a coarse-grained simulation of ∼ 500 proteins inside a cytoplasm like a box with solvent water molecules. The summarized protein interaction networks r esulted from a coarsegrained simulation and large scale protein-protein docking reveals nov el molecular connections and pathways.