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1 2010

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RP-HPTLC determination of the lipophilicity of some new derivatives of thiosemicarbazide and 1,2,4-triazole of sulphanylacetic acid

Hawrył A., Popiołek Ł, Dobosz M., Pikuła E, Waksmundzka-Hajnos M.

Acta Chromatographica

2010

Vol. 22, no. 1

37--55

Some new derivatives of thiosemicarbazide and the 1,2,4-triazole of sulphanylacetic acid have been chromatographed on RP-18 HPTLC plates with mobile phases containing water and an organic modifier (methanol, dioxane, acetone, 2-propanol, or tetrahydrofuran). Relationships between solute retention and modifier concentration were described by Snyder’s linear equation. The equation was used to determine R M 0 values, by extrapolation, and the S values denoting the slopes of the relationship between linear retention and mobile phase concentration; both values characterize the lipophilicity of the substances. Calculated values of R M 0 were correlated with log P values for the drugs investigated by use of the software HyperChem. Correlations between intercept ( R M 0 ) and slope ( S ) from the linear equations were also calculated. The effects of different mobile phase modifiers on experimentally obtained lipophilicity were also analysed and compared.