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Badanie metody przygotowania tabletek z notoginsengiem nowego typu i leczenia ostrego nadwyrężenia mięśni

Liu Qiang

Przemysł Chemiczny

2024

T. 103, nr 4

510--518

Próbki Notoginseng Radix et Rhizoma sproszkowano, ekstrahowano metanolem, sonikowano w 60°C i wirowano przy 4000 rpm przez 5 min. Ekstrakty przefiltrowano przez membranę i zbadano pod kątem składu chemicznego za pomocą wysokosprawnej chromatografii cieczowej w celu wykrycia zawartości ginsenozydów RG1 i RB1. Wyniki były dokładne i charakteryzowały się dobrą powtarzalnością. Metoda ta była zalecana do kontroli jakości i identyfikacji odmian roślin. Jakość tabletek Sanqi Shangyao została skontrolowana podczas nadzoru i inspekcji. Kłącze drynarii (Rhizoma Drynariae) było podstawowym lekiem w tabletkach Sanqi Shangyao z naringiną jako głównym składnikiem. Podano przydatne wskazówki i zalecenia dotyczące zapobiegania i leczenia ostrych urazów mięśni (badania z udziałem studentów i entuzjastów sportu).

Notoginseng Radix et Rhizoma samples were pulverized, extd. with MeOH, sonicated at 60°C and centrifuged at 4000 rpm for 5 min. The exts. were filtered through a membrane and studied for chem. compn. by high-performance liq. chromatog. to det. the ginsenoside RG1 and RB1 contents. The results were accurate with good repeatability. The method was recommended for the quality control and identification of the plant varieties. The quality of Sanqi Shangyao tablets was well controlled in the supervision and inspection. Rhizoma Drynariae was the main drug in Sanqi Shangyao tablets, with naringin as the main component. The useful guidance and ref. for the prevention and treatment of acute muscle injury, based on serving college students and sports enthusiasts was given.

Study on the separation of triterpene saponins from Panax notoginseng by off-line two-dimensional supercritical fluid chromatography–ultrahigh-performance liquid chromatography

Xing Q., Fu Q., Liang X.

Acta Chromatographica

2017

Vol. 29, no. 4

497--502

The off-line two-dimensional supercritical fluid chromatography (SFC)–ultrahigh-performance liquid chromatography (UHPLC) was selected to separate the triterpene saponins from Panax notoginseng. The separation by SFC was performed on an Atlantis® HILIC silica column. Methanol was selected as a modifier, and the most time-saving gradient was developed. The decrease of the column temperature and the increase of the back pressure could shorten the retention time but had no effect on the separation selectivity. Then, the back pressure, column temperature, and flow rate were set as 131 bar, 45 °C, and 4.0 mL min−1, respectively. The retention behavior of the saponins from P. notoginseng was different between SFC and reversed-phase liquid chromatography (RPLC), which facilitated to construct an off-line SFC/RPLC–mass spectrometry (MS) system. In first dimension, a total of eight fractions were collected under SFC and further analyzed by RPLC–MS in second dimension. The result indicated that the retention behavior of triterpene saponins was mainly controlled by the hydrogen bonding interactions which were affected by the number and types of sugars, as well as the aglycone in the structure of triterpene saponins. Thus, the presence of “clustering effect” under SFC was observed, namely, one SFC peak always contained several saponins with same number of sugars and similar structure of aglycone. The clustering effect of triterpene saponins promised SFC to be used as first dimension to complete the preliminary crude separation in the two-dimensional liquid chromatography.