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1 2006

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Badania polimorfizmu związków bioorganicznych metodami spektroskopii NMR w fazie stałej

Kaźmierski S., Potrzebowski M.J.

Wiadomości Chemiczne

2006

[Z] 60, 11-12

723-745

Polymorphism is one of the most important and amazing phenomenon in structural chemistry. The knowledge of this phenomenon is crucial both in experimental sciences (e.g.: chemistry, physics and crystallography) and in industry - especially in pharmaceutical industry. It is well known, that polymorphic forms of therapeutic compounds differ in their bioavailability - e.g. the rate of dissolution and equilibrium solubility. In extreme cases, one polymorph may be a medicine whilst the second may be very dangerous or even poisonous. In this light, the possibility to distinguish the desirable form of compound from the useless form, seems to be very important. In our article, some problems concerning the investigation of polymorphism phenomenon by applications of solid-state NMR are presented. The possibilities of current NMR techniques in searching of polymorphism as well as the practical aspects and applications are presented and discussed.