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Design of a dedicated circular coil for Magnetic Resonance Spectroscopy studies in small phantoms and animal acquisition with a 3 Tesla Magnetic Resonance clinical scanner

Giovannetti Giulio, Flori Alessandra, Marchi De Daniele, Montanaro Domenico, Frijia Francesca

Polish Journal of Medical Physics and Engineering

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2020

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Vol. 26, Iss. 4

269--276

EN

Introduction: Magnetic Resonance Spectroscopy (MRS) is a very powerful tool to explore the tissue components, by allowing a selective identification of molecules and molecular distribution mapping. Due to intrinsic Signal-to-Noise Ratio limitations (SNR), MRS in small phantoms and animals with a clinical scanner requires the design and development of dedicated radiofrequency (RF) coils, a task of fundamental importance. In this article, the authors describe the simulation, design, and application of a 1H transmit/receive circular coil suitable for MRS studies in small phantoms and small animal models with a clinical 3T scanner. In particular, the circular coil could be an improvement in animal experiments for tumor studies in which the lesions are localized in specific areas. Material and methods: The magnetic field pattern was calculated using the Biot–Savart law and the inductance was evaluated with analytical calculations. Finally, the coil sensitivity was measured with the perturbing sphere method. Successively, a prototype of the coil was built and tested on the workbench and by the acquisition of MRS data. Results: In this work, we demonstrate the design trade-offs for successfully developing a dedicated coil for MRS experiments in small phantoms and animals with a clinical scanner. The coil designed in the study offers the potential for obtaining MRS data with a high SNR and good spectral resolution. Conclusions: The paper provides details of the design, modelling, and construction of a dedicated circular coil, which represents a low cost and easy to build answer for MRS experiments in small samples with a clinical scanner.

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Spektroskopia MRS w hodowlach komórkowych in vitro

Truszkiewicz Adrian, Aebisher David, Bartusik-Aebisher Dorota

Inżynier i Fizyk Medyczny

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2020

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Vol. 9, nr 3

175--178

PL

Magnetyczny Rezonans Spektroskopowy (MRS) mimo swojej siedemdziesięcioletniej historii jest dziedziną ulegającą stałemu i niesłabnącemu rozwojowi. Wiąże się to z możliwością wszechstronnego wykorzystania pomiarów MRS zarówno eksperymentalnie do badań podstawowych z zakresu biochemii i fizyki (wyznaczania pewnych parametrów kinetycznych i termodynamicznych), jak i klinicznie w praktyce medycznej. Jako obiekt badań wybrane zostały hodowle komórkowe, a wyniki badania spektroskopowego w hodowlach komórek nowotworowych są prezentowane w niniejszym opracowaniu. Celem pracy była optymalizacja pomiaru spektroskopowego w hodowlach komórkowych na średniopolowym systemie magnetycznego rezonansu jądrowego. Zapotrzebowanie na jakościowe i ilościowe analizy zawartości aminokwasów w mediach i różnych płynach fizjologicznych i poznanie składu mieszanin aminokwasów białek spowodowało rozwój wielu technik spektroskopowych, m.in. MRS.

EN

Magnetic Resonance Spectroscopy (MRS), despite its seventy years of history, is a field undergoing constant and uninterrupted development. This involves the possibility of comprehensive use of MRS measurements both experimentally for basic research in the field of biochemistry and physics (determination of certain kinetic and thermodynamic parameters) as well as clinically in medical practice. Cell cultures were chosen as the object of research and the results of spectroscopic examination in cancer cell cultures are presented in this study. The aim of the work was to optimize spectroscopic measurement in cell cultures on a medium-field nuclear magnetic resonance system. The need for qualitative and quantitative analysis of the content of amino acids in the media and various physiological fluids and knowledge of the composition of amino acid mixtures of proteins has resulted in the development of many spectroscopic techniques, among others MRS.

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Kontrola jakości w spektroskopii 1H MRS

Skorupa A., Sokół M., Wicher M.

Inżynier i Fizyk Medyczny

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2016

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Vol. 5, nr 6

323--328

PL

Spektroskopia rezonansu magnetycznego in vivo (MRS) jest nieinwazyjnym narzędziem pozwalającymbadać procesy zachodząceworganizmach żywych na poziomiemolekularnym. Możliwość ilościowej analizy biochemicznej wybranego obszaru zainteresowania czyni tę technikę cenną, zwłaszcza w zastosowaniu do wspomagania diagnostyki zmian w mózgu. Jeśli jednak MRS ma znaleźć swoje stałe miejsce w praktyce klinicznej, wymaga prostego i wiarygodnego systemu kontroli jakości QC (Quality Control) oraz standaryzacji technik akwizycji widm i wysokiej jakości danych spektroskopowych. Kontrola jakości procedur MRS jest zatem niezbędna zarówno, by upewnić się, że system MR jest optymalnie skalibrowany do badań spektroskopowych, jak i na etapie zbierania danych i ich przetwarzania. W artykule przedstawiono ogólną strategię funkcjonowania systemu QC na obu poziomach, opisano podstawowe testy, wskazano sugerowane kryteria ich akceptacji i podanoogólne zasady analizy widm MR.

EN

Localized Magnetic Resonance Spectroscopy (MRS) is a nuclear magnetic resonance-based technique that allows in vivo non-invasive measurements of biomolecules. The feasibility of acquiring quantitative biochemical information from a certain region of interest makes this technique especially valuable in assisting the diagnosis of brain lesions. However, if MRS is to be used in clinical practice, it requires a simple and reliable system of quality control (QC), standardization of acquisition of spectra and collecting high quality spectroscopic data. The MRS quality control system is, thus, necessary both, to ensure that MR system is optimally calibrated for spectroscopic studies, as well as it is required at the time of data acquisition and data post-processing. This paper outlines a recommended general QC testing strategy, overviews some basic tests, provides their suggested acceptance criteria and describes the general aspects of post-processing of MR spectra.

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On the Influence of Low-Frequency Magnetic Field Disturbances on Basic High Resolution NMR Experiments

Kazimierczuk K., Koźmiński W.

Polish Journal of Chemistry

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2006

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Vol. 80, nr 7

1119-1124

EN

CDPcholine (citicoline, CDPCho) shows beneficial effects in various Central Nervous System (CNS) injury models and neurodegenerative diseases. Previous studies demonstrate conflictingMagnetic Resonance Spectroscopy (MRS) reports regarding the impact of different choline-containing compounds and its doses on brain metabolites. This preliminary study was designed to evaluate concentration changes of brain MR-visible metabolites following intravenous CDPCholine. Twelve healthy rats treated with CDPCholine in three subsequent doses of 1gram/kg eachwere examined using 1Hand 31P MRS in vivo. Following intravenous CDPCholine administration there was a statistically significant increase of the Cho/Cr ratio after first CDPCholine injection. The evidence of CDPcholine influence on brain metabolites has been shown.

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Assessment of Metabolite Concentrations Changes in Rat Brain after Intravenous CDPcholine Injection Using Magnetic Resonance Spectroscopy in vivo

Kulinowski P., Labak M., Majcher K., Herbik A., Grieb P., Jasiński A.

Polish Journal of Chemistry

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2006

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Vol. 80, nr 7

1125-1132

EN

CDPcholine (citicoline, CDPCho) shows beneficial effects in various Central Nervous System (CNS) injury models and neurodegenerative diseases. Previous studies demonstrate conflictingMagnetic Resonance Spectroscopy (MRS) reports regarding the impact of different choline-containing compounds and its doses on brain metabolites. This preliminary study was designed to evaluate concentration changes of brain MR-visible metabolites following intravenous CDPCholine. Twelve healthy rats treated with CDPCholine in three subsequent doses of 1gram/kg eachwere examined using 1Hand 31P MRS in vivo. Following intravenous CDPCholine administration there was a statistically significant increase of the Cho/Cr ratio after first CDPCholine injection. The evidence of CDPcholine influence on brain metabolites has been shown.