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1 Polish Journal of Chemistry

1 2008

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Designing and Synthesis of a Highly Symmetric and Conjugated Macrocyclic Knoevenagel Schiff Base Model Ligand and Its Transition Metal Complexes : Spectral Characterization, Antimicrobial Activity and DNA Cleavage Studies

Raman N., Parameswari S.

Polish Journal of Chemistry

2008

Vol. 82, nr 7

1331-1334

A novel macrocyclic Knoevenagel Schiff base ligand has been designed and synthesized using 3-cinnamalideneacetoacetanilide and 4,4'-diaminodiphenylmethane. It acts as a tetradentate and strongly conjugated to form acationic solid complex with CuCl2/NiCl2/CoCl2/ZnCl2/MnCl2/CdCl2/HgCl2/VOSO4. The formed ligand and the complexes were characterized by usual spectral and analytical techniques. All the synthesized complexes were characterized by microanalytical data, magnetic susceptibility measurements, IR, UV-Vis, 1H-NMR, ESR and mass spectral techniques. They exhibit square-planar geometry except oxovanadium complex, which has square-pyramidal geometry. The electrolytic behaviour and monomeric nature of the com plexes were confirmed from their conductance data and magnetic susceptibility values. The X-band ESR spectra of Cu(II) and VO(IV) complexes in DMSO at 300 and 77 K were recorded and their salient features are reported. The in vitro antimicrobial activi ies of the investigated compounds were tested against few microorganisms by well-diffusion technique. It was found that the metal complexes have higher activity than the ligand. The cleavage activity of all the complexes was examined on CT-DNA using gel electro phoresis experiment in the presence of H2O2. From the data, it was found that oxovanadium, zinc and manganese complexes cleave DNA through redox chemistry.