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HPLC determination of K027 in the body of pregnant mice

Nurulain S. M., Ojha S., Dhanasekaran S., Kuča K., Nalini N., Sharma C., Adem A., Kalász H.

Acta Chromatographica

2017

Vol. 29, no. 1

85--93

Distribution of K027, a hydrophilic, positively charged compound is monitored in the body of pregnant mice using high-performance liquid chromatography (HPLC). Intraperitoneal injection was done on the 18th day of pregnancy; the plasma and brains of the mother mice, placentae and the fetuses’ brains were dissected following 5, 15, 30, 60, and 120 min of treatment. Significant incorporation of K027 was found in the placentae and in fetuses’ brains relative to its levels in the mothers’ plasma and brains. This incorporation warns of a possible adjustment of dose of pyridinium aldoxime antidotes in case of pregnancy. Further studies with different gestational periods and animal models are warranted.

HPLC analysis in drug level monitoring of K027

Nurulain S. M., Kalász H., Szegi P., Kuca K., Adem A., Hasan M. Y. B., Hashemi F., Tekes K.

Acta Chromatographica

2013

Vol. 25, no. 4

703--710

HPLC monitoring of pharmacokinetics was done in two body compartments of rats following intramuscular treatments with three different doses of K027, a bispyridinium mono-aldoxime type of antidotes to organoposphate intoxicated subjects. Reversed-phase HPLC separation with electrochemical detections was done to monitor the onset, the maximum level, and offset in K027 concentration. Serum level of K027 showed a fast onset, independently from the doses of K027. Drug level in brain was showing an essentially delayed kinetics.