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1 Polish Journal of Chemistry

1 2008

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Synthesis, Characterization, in-vitro Biocidal and Nuclease Activity of Cu(II), Fe(II) and Fe(III) Complexes

Pansuriya P. B., Chhasatia M. R., Patel S. H., Patel M. N.

Polish Journal of Chemistry

2008

Vol. 82, nr 8

1527--1539

Complexes of Cu(II), Fe(II), and Fe(III) have been synthesized by reaction of their metal salts with bis(4-hydroxy-2oxo-2H-chromen-3-yl)-methane or bis(4-hydroxy-2oxo-2Hchromen- 3-yl)-thiophene-2yl-methane or bis(4-hydroxy-2oxo-2H-chromen-3-yl)-pyri -din-3yl-methane in molarratio 1:2. They have been characterized using 1H-NMR, 13C-NMR, IR spectra, electronic spectra, magnetic measurements and elemental analyses and screened for their in-vitro antimicrobial activity against Bacillus cereus, Staphylococcus aureus, Escherichia coli, Bacillus subtilis, Salmonella typhi, and Serratia marcescens. The metal complexes exhibit moderate antimicrobial activity compared to parental compounds and standard drugs. In-vi tro nuclease activity has been determined using agarose gel electrophoresis. The synthesized compounds show effective nuclease activity.