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Synthesis and Antimicrobial Activity of 2-{4'-[(6"-aryl)2"-hydroxy-3",4"-dihydro-pyrimidine-4"-yl]-phenyl amino}-6-[bis (2'"-chloroethyl) amino]-4-Methoxy-1,3,5-Triazine

Kathiriya P. J., Purohit H. D., Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 49

137--142

The titled compounds (5a-5k) have been synthesized by the condensation of 2-{4'-[(3"-aryl)-2"-Propene-1"-one]-Phenyl amino}-6-[bis-2""-chloroethyl) amino]-4-methoxy-1,3,5-triazine with urea in presence of conc. HCl (0.3ml) The biological activities of these compounds have been examined against various Gram +ve, Gram –ve bacteria and fungi. The structure of the products was confirmed by IR, 1H NMR, Mass spectra and elemental analysis.