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Analysis of susceptibility loci for juvenile idiopathic arthritis in the extended Mhc region using high resolution Snp and Hla allele typing

Biesiada J., Sudman M., Wagner M., Rupert A., Hollenbach J., Haas J. P., Meller J., Thompson S. D.

TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk

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2014

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Vol. 18, No 4

305--320

EN

Juvenile idiopathic arthritis ( JIA ) spans several pediatric arthropathies that involve autoimmune responses. Primary genetic risk factors for JIA have been mapped to Major Histocompatibility Complex ( MHC ) class I and class II genes. Recent genome-wide association studies using SNP arrays have shown that the nonHLA genetic component of JIA involves multiple low-risk loci, reinforcing the notion that JIA is a complex genetic trait with a strong HLA component. In this work, with the goal of detailed mapping and analysis of lin kage disequilibrium ( LD ) patterns and associations with JIA in the extended MHC (x MHC ) region, we combined SNP data from Affymetrix SNP Array 6.0 and Immunochip ( IC ) platforms with high resolution typing of 8 classical HLA genes. A cohort of about 800 affected individuals and about 500 ethnically matched controls from the Cincinnati region, as well as secondary validation cohorts of affected individuals and matched controls from Germany were used to perform the an alysis, and to assess reproducibility of the results across different platforms and p opulations. Accurate high resolution maps of linkage with classical HLA genes and association with individual HLA alleles were generated. High concordance of results obtained using Affymetrix SNP Array 6.0 and IC was observed, with an additional resolution and improved mapping of associat ions provided by the latter in some regions. Several new peaks of statistically signific ant and reproducible association with JIA outside the regions of strong LD with classical HLA genes were observed, including one peak in the class III region, and one in the telomeric end of x MHC . Conditional analysis provided further evidence that these associations appear t o be independent of classical HLA genes studied here. The results and observed association patterns ar e further discussed in the context of other recent studies on autoimmune diseases, includin g the role of HLA DRB 1 in adult Rheumatoid Arthritis.

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VBS2 - nowoczesne środowisko trójwymiarowego zobrazowania

Stopniak M.

Szybkobieżne Pojazdy Gąsienicowe

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2012

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nr 3 (31)

97--106

PL

VBS2 (ang. Virtual Battle Space 2) to nowoczesne narzędzie informatyczne pozwalające na projektowanie symulatorów i trenażerów. W artykule pokazano możliwości środowiska trójwymiarowej wizualizacji pola walki VBS2. Omówiono najważniejsze moduły oprogramowania zapoznając Czytelnika z zakresem możliwości systemu. Przedstawiono też najważniejsze zalety środowiska VBS2.

EN

VBS2 (Virtual Battle Space 2) is a modern computer software for designing simulators and training equipment. The most important modules/packages of the software are shown to illustrate the capabilities of the system. It shows the most important software modules, bringing the reader to the scope of its capabilities. Major advantages of the VBS2 environment are given.

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Interactive Grid computing: adapting high level architecture-based applications to the Grid

Rycerz K., Bubak M., Malawski M., Sloot P.

TASK Quarterly : scientific bulletin of Academic Computer Centre in Gdansk

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2004

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Vol. 8, No 4

549-559

EN

In this paper we present the design of a Grid HLA Management System (GHMS) supporting execution of High Level Architecture-based interactive applications in a Grid environment, while at the same time allowing for running HLA legacy codes to preserve backward compatibility with the HLA standard. In particular, we describe the following system components: an HLA-Speaking Service for multiple federates that interface the HLA application to the system, a Monitoring Service integrated with the OCMG monitoring system and HLA-based Benchmark Services informing the Broker Service of what can be expected from the application's behavior.

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Interfacing war game simulations with tactical C2 systems - dream or reality?

Šnajder M., Holden P.W.

Journal of Telecommunications and Information Technology

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2003

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nr 4

57-65

EN

Decision making process in current tactical C2 systems is base on planning process of commanders and their staff. Improving tactical decision making by interfacing war game simulations with tactical C2 systems is achievable. Commander can review the results of the simulation and subsequently modify the tactical plan. Previously, the use of "training" simulations was not a viable solution to real world decision making due to the lengthy time required to input all of the combat entities, the unit organizations and personnel dispositions, the equipment configurations, status of the units and equipment, and the distribution of the available supplies. Modern C2 systems have all of this information stored in the common system databases, and this information can be used to instantiate and populate the simulation through an electronic adaptation of the data structures to match the requirements of the constructive simulation. This paper will provide description of system approach of interfacing simulation and C2 system to improve decision-making.