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Application of an ultra-high dose rate (FLASH) proton beam for the 3D cancer cell model - a proof of concept

Durak-Kozica Martyna, Stępień Ewa, Swakoń Jan, Moskal Paweł

Bio-Algorithms and Med-Systems

2023

Vol. 19, no. 1

31--34

Ultra-high dose rate (FLASH) proton radiotherapy is a promising treatment method for cancer patients. In our research, we want to compare the FLASH method with a conventional radiation method to show what effect they have on the biochemical structure of the tumour (3D model - spheroids) and the secretion of extracellular vesicles (EVs) and their cargo. The use of a modern method of creating spheroids will enable us to create conditions that are better able to mimic the tumour microenvironment.