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Properties of D-optimal sampling schedule for compartmental models

Kalicka R., Bochen D.

Biocybernetics and Biomedical Engineering

2005

Vol. 25, no. 1

23-36

Software allowing visualization of D-optimal objective function distribution over multidimensional time space was designed and implemented. The analysis was performed for one, two and three-compartmental models. Outputs of the models have form of sums of exponential terms. The exemplary objective functions distribution and searching algorithm are presented. The obtained results show that objective function for D-optimal solution has no local extremes. The problem under investigation has one globally optimal solution.