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1 2015

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Synthesis and Antimicrobial Screening of 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo[1, 2-a]pyridine -3-yl]-6"-aryl-4"-H-pyran-3"- Carbonitrile

Bhuva V. V., Bhadani V. N., Purohit H. D., Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 49

149--154

3-Cyano-4,6-disubstituted 4H-pyrans are endowed with a variety of pharmacodynamic activities Looking to the interesting properties of cyanopyrans, it was considered worthwhile to synthesis some new 2"-amino-4"-[2-(4'-chlorophenyl) -6-methyl imidazo [1,2-a] pyridin-3-yl]-6"-aryl-4"-H-pyran-3"- carbonitrile ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/mL. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.