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2 International Letters of Chemistry, Physics and Astronomy

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Spectral and Microbial Studies of some Newly Synthesized Schiff Base Derivatives of 2-(1H-benzo[d]oxazole-2-ylthio)-N-(4-acetylphenyl)acetamide

Maru J.J., Patel G. R., Yadav R.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 44

57--65

The author has synthesized novel biological active compounds by condensation of N-(4-Acetyl-phenyl)-2-(benzooxazol-2-ylsulfanyl)-acetamide with defferent substituted of acid hydrazide in the presence of catalytic amount of acetic acid. A series of benzoxazole having azomethine group were confirmed by various spectroscopic techniques. The new compounds were examined for antibacterial effects again different strain of bacteria and antifungal were high to lowest Minimum Inhibition Concentration (MIC) values.

Easy, Simplistic and Green Synthesis of Various Benzimidazole and Benzoxazole Derivatives Using PEG400 as a Green Solvent

Khunt M. D., Kotadiya V. C., Viradiya D. J., Baria B. H., Bhoya U. C.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 6

61--68

An improved environmentally benign procedure for the synthesis of various benzimidazole and benzoxazole derivatives using green solvent PEG400. We have optimized the reaction condition and it was found that PEG400 was believed to be best as compared to PEG200, PEG600 and PEG800 at 80 to 85 °C. This method provides a novel route for the synthesis of benzimidazole and benzoxazole derivatives. The main attractive features of this process are a mild reaction conditions, easy workup procedure and good to excellent yield. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis.