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Antimicrobial Screening of Synthesized some Novel Azomethines via Organic Base

Patel G.R., Maru J.J., Yadav R.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 43

25--33

The author has synthesized azomethines in which carbonyl group is replaced by amine of acid hydrazides. The intermediates were prepared by using 2-mercapto benzimidazole with N-(4-Acetyl-phenyl)-2-chloro-acetamide in the presence of K2CO3. The Resulted product was further treated with different substituted of acid hydrazide in ethanol to yield the titled compounds using a catalytic amount of acetic acid. New products were examined for their antibacterial effects against Gram-positive and Gram-negative strains and antifungal were highly potent with lowest MIC Values. The structural assignments of the new products were done on the basis of FT-IR, NMR, Mass spectroscopy and elemental analysis.

Synthesis and characterization of some thiazolidinone derivatives possessing benzimidazole nucleus

Mehta P., Dawedra P., Goswami V., Joshi H. S.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 11, iss. 1

1-8

Synthesis of new thiazolidinone derivatives possessing benzimidazole nucleus by condensation reaction of various substituted mercapto acids in presence of anhydrous ZnCl2. In our present study we have also synthesized Schiff bases of benzimidazole derivatives. All synthesized compounds were characterized by IR, 1H NMR and Mass spectroscopy.

Easy, Simplistic and Green Synthesis of Various Benzimidazole and Benzoxazole Derivatives Using PEG400 as a Green Solvent

Khunt M. D., Kotadiya V. C., Viradiya D. J., Baria B. H., Bhoya U. C.

International Letters of Chemistry, Physics and Astronomy

2014

Vol. 6

61--68

An improved environmentally benign procedure for the synthesis of various benzimidazole and benzoxazole derivatives using green solvent PEG400. We have optimized the reaction condition and it was found that PEG400 was believed to be best as compared to PEG200, PEG600 and PEG800 at 80 to 85 °C. This method provides a novel route for the synthesis of benzimidazole and benzoxazole derivatives. The main attractive features of this process are a mild reaction conditions, easy workup procedure and good to excellent yield. The structures of all the synthesized compounds were confirmed by 1H NMR, IR, MASS and Elemental Analysis.