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2 International Letters of Chemistry, Physics and Astronomy

2 2015

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Synthesis, Spectral Studies Antibacterial and Antifungal Activity of 2" – Amino - 4" - [2 - (4' -chlorophenyl)-6-methyl imidazo[1, 2-a] pyridin-3-yl]-6"-aryl Nicotinonitrile

Bhuva V. V., Bhadani V. N., Purohit H. D., Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 49

161--166

Pyridine nucleus plays an important role in medicine, agriculture and industrial chemistry. With a view of biological activities and variety of industrial applications, some new 2" – amino - 4" - [2 - (4' -chlorophenyl)-6-methyl imidazo [1, 2-a] pyridin-3-yl]-6"-aryl nicotinonitriles ( 4a-4l ) have been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.

Synthesis, Spectral Studies and Biological Screening of 2-(4'-chlorophenyl)-6-methyl-(3-N, n’-Diaryl/Dialkyl Amino methyl)-imidazo[1,2-a]pyridine

Bhuva V. V., Bhadani V. N., Purohit H. D., Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 49

167--171

2-(4'-chlorophenyl)-6-methyl- (3-N, N'- diaryl/dialkyl amino methyl)-imidazo [1, 2-a] pyridine (4a-4l) has been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50μg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.