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1 International Letters of Chemistry, Physics and Astronomy

1 2015

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Antimicrobial Screening of Synthesized some Novel Azomethines via Organic Base

Patel G.R., Maru J.J., Yadav R.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 43

25--33

The author has synthesized azomethines in which carbonyl group is replaced by amine of acid hydrazides. The intermediates were prepared by using 2-mercapto benzimidazole with N-(4-Acetyl-phenyl)-2-chloro-acetamide in the presence of K2CO3. The Resulted product was further treated with different substituted of acid hydrazide in ethanol to yield the titled compounds using a catalytic amount of acetic acid. New products were examined for their antibacterial effects against Gram-positive and Gram-negative strains and antifungal were highly potent with lowest MIC Values. The structural assignments of the new products were done on the basis of FT-IR, NMR, Mass spectroscopy and elemental analysis.