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Comparison of the WHO classification (5th edition) 2022 and the International Consensus Classification (ICC) 2022 for diagnosis of acute myeloid leukemia

Al-Nakkash Naba, Frenzel Lukas P.

Scientiae Radices

2024

Vol. 3, Iss. 1

14--29

In 2022, two classifications were published to define the diagnosis of patients with acute myeloid leukemia (AML). The World Health Organisation (WHO) 5th edition and the International Consensus Classification (ICC) provide an updated summary of current knowledge of the diseases and construct a framework for physicians. Two differing classifications result in discrepancies, which change the definition of AML subtypes and present a challenge in clinical settings. This work summarizes the updated classification systems and discusses their significance in clinical settings while considering the latest findings. Relevant changes affect the i) required blast percentage, ii) AML harbouring CEBPA mutations, iii) AML with KMT2A and MECOM rearrangements, iv) AML with myelodysplasia-related characteristics and in association with this entity AML with mutated RUNX1, and lastly v) AML with TP53 mutation. In summary, a unified classification system would be desirable to achieve harmonized diagnosis and treatment of AML).

The cryptocurrency AML challenge - sanction 2022 new threats

Przyłuski Kamil

Zeszyty Naukowe. Organizacja i Zarządzanie / Politechnika Śląska

2022

z. 162

623--630

Purpose: Paper reviews changes taking place in the cryptocurrency market after the introduction of further sanctions on the Russian financial market. The author notes that cryptocurrencies are used more and more often by companies operating in Russia. The cryptocurrency market remains largely beyond control despite the AML area. It is a source of many threats of money laundering. The paper recapitulates the status of the global trade market choosing settlement cryptocurrency in the context of anti-money laundering. Methodology: The analysis was based on reports on the market quotation of popular cryptocurrencies. Findings: The paper includes definitions of new challenges for AML areas. Practical implications: (if applicable) What outcomes and implications for practice, applications and consequences are identified? How will the research impact the business or enterprise? What changes to practice should be made as a result of this research? What is the commercial or economic impact? Not all papers will have practical implications. Social implications: The application of the proposed solutions will improve the security systems of financial sector institutions. Originality/value: The paper provides guidance on how to assess institutional capacity and support the anti-money laundering process.