Wyniki wyszukiwania - BazTech

Ograniczanie wyników

Znaleziono wyników: 1

Liczba wyników na stronie

Wyniki wyszukiwania

Wyszukiwano:
w słowach kluczowych: 2-pyridinecarboxylic acid hydrazide

Sortuj według:

Ogranicz wyniki do:

Rate and Equilibrium in Aqueous 1:2 Chelation of Copper(II) by 2-Pyridinecarboxylic Acid Hydrazide. Antituberculosis Activity

Hernando J., Blanco C. A., Caballero I., Prieto T.

Polish Journal of Chemistry

2002

Vol. 76 / nr 12

1673-1680

Chelation reactions of 2-pyridinecarboxylic acid hydrazide, widely used drug in antituberculous regimens, with copper(II) have been investigated in aqueous solution at a temperature of 25_C. The ionization equilibria of the ligand and the stability of the metal-ligand complexes have also been characterized. Kinetic results show that the rate constant for monochelated complex formation is several times larger than the rate constant for dichelated complex formation. Adetailed mechanism is proposed to account for the kinetic data.