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2 International Letters of Chemistry, Physics and Astronomy

2 2015

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Synthesis, Spectral Studies, Antibacterial and Antifungal Activity of 2" – Methoxy - 4" -[2 - (4' -chlorophenyl)-6-Methyl Imidazo [1, 2-a] Pyridin-3-yl]-6"-Aryl Nicotinonitrile

Bhuva V. V., Bhadani V. N., Purohit H. D., Purohit D. M.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 49

155--160

Pyridine nucleus plays an important role in medicine, agriculture and industrial chemistry. With a view of biological activities and variety of industrial applications, some new 2" – methoxy - 4" - [2 - ( 4' -chlorophenyl)-6-methyl imidazo [1, 2-a] pyridin-3-yl]-6"-aryl nicotinonitrile( 4a-4l ) has been synthesized. The products have been assayed for their biological activity against Gram +ve, Gram –ve bacteria and fungi. Some of the products showed moderate activity in concentration 50µg/ml. The structures of the products have been elucidated by IR, 1H-NMR, Mass spectral data, elemental analysis and thin layer chromatography.

Synthesis and Antimicrobial Activity of (2-methoxy/2-amino)-6-{4'-[(4'''-chlorophenyl) (phenyl) methyl amino] phenyl}-4-Aryl Nicotinonitrile

Guna J. V., Bhadani V. N., Purohit H. D., Purohit M. D.

International Letters of Chemistry, Physics and Astronomy

2015

Vol. 49

99--103

2- Methoxy – 6 - {4' - [(4'''- Chlorophenyl) (phenyl) methyl amino] phenyl} - 4 - aryl nicotinonitrile (3a-3l) and 2-Amino-6-{4'-[(4'''-Chlorophenyl)(phenyl)methyl amino]phenyl}-4-aryl nicotinonitrile (4a-4l) have been synthesized. The products have been assayed for their antimicrobial activity against Gram +ve, Gram -ve bacteria and fungi. The structure of the products has been elucidated by IR, 1H-NMR, mass spectral data, elemental analysis and thin layer chromatography.