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1 2022

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2,3-dihydro-quinazolin-4(1H)-one as a fluorescent sensor for Hg2+ ion and its docking studies in cancer treatment

Mohhamadi Ziarani Ghodsi, Tahmasebi Ashtiani Shadi, Mohajer Fatemeh, Badiei Alireza, Gaikwad Sunil V., Varma Rajender S.

Chemistry-Didactics-Ecology-Metrology

2022

R. 27, NR 1-2

25--33

The 2,3-dihydro-quinazolin-4(1H)-one was synthesised via the deployment of SBA-Pr-SO3H and its application was explored as a highly selective fluorescent sensor for Hg2+ ion; fluorescence intensity was decreased selectively by Hg2+ ions. Furthermore, this compound also indicated for its superb anti-interference ability among other ions. It is important to mention that this compound could be employed to detect a very low amount of Hg2+ ions, which are highly toxic and general contaminants. The docking study shows that the molecule, 2,3-dihydro-quinazolin-4(1H)-one, is a good inhibitor for the 5ACC enzyme.