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1 2007

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Synthesis of New 2-Aminobenzimidazole Derivatives. Part 4. Reactions of 2-Arylideneaminobenzimidazole with Selected -Ketoesters

Nawrocka W. P., Kowalska M. W., Sztuba B., Dryś A., Wietrzyk J., Filip B.

Polish Journal of Chemistry

2007

Vol. 81, nr 10

1753-1753

Schiff bases 2–6 obtained from 2-aminobenzimidazole 1 with p-(N,N-diethylamino)-, p-chloro-, p-bromo-, 2,4-dimethoxy-, and 3,4-dimethoxybenzaldehyde were subjected to the reaction with 1,3-ketoester: methyl-, ethyl-, benzyl-, and t-butylacetoacetate to form derivatives of pyrimido[1,2-a]benzimidazole 7–23. 1H NMR spectra recorded for the compounds 20–23 in DMSO solution indicate the presence of two conformational forms. Compounds 2, 7–23 were examined for their antiproliferative activity in vitro against the cells of human lung cancer cell lines A549.