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2 Polish Journal of Chemistry

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Synthesis and Antiproliferative Activity in vitro of New 2-Aminobenzimidazole Derivatives. Part 3 [1]. Reactions of 2-Arylideneaminobenzimidazole with Selected 1,3-Diketones

Nawrocka W., Sztuba B., Dryś A., Wietrzyk J., Kosendiak J., Opolski A.

Polish Journal of Chemistry

2006

Vol. 80, nr 2

279-287

A series of pyrimido[1,2-a]benzimidazole derivatives has been synthesized in the reactions of 2-aminobenzimidazole Schiff bases 1-6 with selected _-diketones; acetylacetone 7-12 or benzoylacetone 13-18. The structures 4, 7-18 were confirmed by the results of elemental analysis and their IR, 1H NMR and MS spectra. Compounds 4, 7-18 were examined for their antiproliferative activityin vitro against 3 cancer cell lines: P338 (mice leukemia), A549 (non-small cell lung carcinoma), SW707 (rectal adenocarcinoma), using SRB (sulphorhodamine B) or MTT (3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyl tetrazolium bromide) technique. The Schiff base 4 and tricyclic derivatives 9, 14, 16 exhibited the highest cytotoxic activity in vitro.

Voltammetric study of the Reduction of Triptindanones in N,N-Dimethylformamide

Jaworski J., Kuck D.

Polish Journal of Chemistry

2004

Vol. 78 / nr 9

1597-1604

The mechanism of electroreduction of 9-triptindanone (1), 9,10-triptindanedione (2), and 9,10,11-triptindanetrione (3) was studied by use of the cyclic voltammetric method. All carbonyl groups were reduced giving one, two, and three one-electron cathodic peaks for 1, 2, and 3, respectively and the corresponding oxidation peaks. The first electron transfer is reversible and the radical anions formed are stable. Additional small peaks for 2 and 3 were discussed in terms of an adsorption of reactants and intermediates and their reactions with the participation of supporting electrolyte cations as well as the residual water.