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1 Polish Journal of Chemistry

1 2007

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Highly Efficient and Regioselective Phosphorylation of Sphingolipids by Phase-Trans fer Catalysis

Szulc Z. M., Obeid L. M., Hannun Y. A., Bielawska A.

Polish Journal of Chemistry

2007

Vol. 81, nr 11

1899-1909

Phosphorylation of D-erythro-sphingosine and its N-BOC or N-palmitoyl derivatives with trimethyl phosphite was carried out in 72–92% yield at room temperature for 20 min in a biphasic system comprised of dichloromethane/aqueous solutions of NaOH or K2CO3 using 1,2-dibromotetrachloroethane as a source of halogen and cetylpyridinium bromide as a phase-transfer catalyst. These are the first reported examples of a highly selective O- and N-phosphorylation of sphingolipids by the phase-transfer catalysis. Our studies show that the developed phosphorylation protocol works as a modular process, in which the synthetic out come is controlled by a type of the used base, catalyst and solvent system.