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Haemocompatibility and cytotoxic studies of non-metallic composite materials modified with magnetic nano and microparticles

Szymonowicz M., Rybak Z., Fraczek-Szczypta A., Paluch D., Rusak A., Nowicka K., Blazewicz M.

Acta of Bioengineering and Biomechanics

2015

Vol. 17, no. 3

49--58

Purpose: Preventing the formation of blood clots on the surface of biomaterials and investigation of the reasons of their formation are the leading topics of the research and development of biomaterials for implants placed into the bloodstream. Biocompatibility and stability of a material in body fluids and direct effect on blood cell counts components are related both to the structure and physico-chemical state of an implant surface. The aim of this study was to determine haemocompatibility and cytotoxicity of polysulfone-based samples containing nano and micro particles of magnetite (Fe3O4). Methods: The polysulfone-based samples modified with nanometric and micrometric magnetite particles were examined. Physicochemical properties of the composites were determined by testing their wettability and surface roughness. The action of haemolytic, activation of coagulation system and cytotoxicity of composites was evaluated. Results: Wettability and roughness of materials were correlated with nanoparticles and microparticles content. In the tests of plasma coagulation system shortening of activated partial thromboplastin time for polysulfone with nano magnetite and with micro magnetite particles was observed in comparison with pure polysulfone. Prothrombine time and thrombine time values as well as fibrinogen concentration were unchanged. Haemolysis values were normal. Morphology and viability of cells were normal. Conclusions: Composites made from polysulfone modified with nanoparticles and microparticles of magnetite cause neither haemolytic nor cytotoxic reaction. These composites evoke plasma endogenous system activation.

Komórkowe efekty oddziaływania wolnozmiennych pól magnetycznych

Sieroń A., Kawczyk-Krupka A.

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

1998

Vol. 4, nr 3

79-85

Prace eksperymentalne na modelu komórkowym wykazują różnorodne działanie biologiczne wolnozmiennych pól magnetycznych, zależnie od parametrów fizycznych pól: indukcji, częstotliwości, kształtu fali oraz od czasu ekspozycji. Wolnozmienne pola magnetyczne modyfikują różnorodne funkcje życiowe, ekskrecję, podziały komórkowe, a także ekspresje genów. Eksperymenty przeprowadzane na hodowlach komórkowych pozwalają na obiektywną ocenę efektu działania wolnozmiennych pól magnetycznych na struktury subkomórkowe.

Experimental studies at the cellular level have demonstrated various biological effects of the magnetic fields. Studies with cellular systems using different exposure regimes durations, amplitudes, frequencies and waveforms indicate, that biological effects of magnetic fields on cellular systems may be related to cell viability, multiplication, gene expression, cellular excretion, or even tumour promotion. The experiments performed on tissue cultures seem to give better insight into the effects evoked by magnetic field within a single cell and its subcellular organelles.