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1 Prace Naukowe Politechniki Warszawskiej. Elektronika

1 2006

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Od praktyki klinicznej do modelowania matematycznego mózgu i z powrotem

Czosnyka M., Smielewski P., Piechnik S., Czosnyka Z.

Prace Naukowe Politechniki Warszawskiej. Elektronika

2006

z. 157

9-17

Complexity of brain monitoring in clinical practice stimulated many studies on mathematical models. Most of available brain signaIs as intracranial pressure, cerebral blood flow, brain tissue oxygenation, etc., can be measured only invasively or indirectly. Function of the mathematical models is to extrapolate limited direct information derived trom few accessible modalities to complex descriptors which cannot be directly measured, such as compliance of craniospinal axis or autoregulation of cerebral blood flow. Three models deseribing cerebrospinal fluid pressure-volume compensation, cerebral blood flow and bihemispherical haemodynamics are presented along with examples, how their application may help in development ofnew diagnostic methods applicable in clinical neurosciences.