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Ca-deficient hydroxyapatite scaffolds from injectable calcium phosphate/chitosan cements

Rajzer I., Castano O., Engel E., Planell J. A.

Engineering of Biomaterials

2010

Vol. 13, no. 92

2--4

Calcium phosphate cement (CPC) has been success-fully used in bone tissue regeneration for many years. However, poor mechanical properties and low biodegradation rate limit any further applications. R-cement has a higher solubility than conventional CPC and its reaction products (CDHA) are similar to the mineral phase of bone. In this work we have developed new CPC composition which consists of a mix of cement R, glycerol as a liquid phase carrier and a biodegradable hydrogel (chitosan) which acts as a binder and was incorporated into R-cement to strengthen this biomaterial. The cement past was found to be stable in a syringe (even after two month of storage in the freezer) and hardened only after being exposed to biological fluids.

An ultrasonic method for estimation of elastic properties of R-bone cement after immersion in Ringer's solution

Rajzer I., Piekarczyk J., Castano O., Engel E., Planell J. A.

Engineering of Biomaterials

2008

Vol. 11, no. 81-84

113--116

The aim of this investigation is to establish an improved non-destructive ultrasonic through-transmission technique to monitor the setting behaviour of calcium phosphate cement samples. On the basis of ultrasound techniques the elastic properties of cement paste after different soaking time in Ringer's solution were measured. Young's modulus, the rigidity modulus, and Poisson's ratio were calculated from measurements of density and ultrasonic longitudinal and shear wave velocities.