Wyniki wyszukiwania - BazTech

Ograniczanie wyników

1 Nukleonika

1 2012

Powiadomienia systemowe

Sesja wygasła!

Znaleziono wyników: 1

Liczba wyników na stronie

Wyniki wyszukiwania

Sortuj według:

Ogranicz wyniki do:

Biokinetics and radiation dosimetry for [4-14C] cholesterol in humans

Marcato L. A., Hamada M. M., de Mesquita C. H.

Nukleonika

2012

Vol. 57, No. 4

607-613

This study proposes a biokinetic model for using in the assessment of the internal dose received by human subjects administered intravenously or orally with [4-14C]-cholesterol. The proposed model includes three systemic pools representing the short-term (T1/2 = 1 d), intermediate-term (T1/2 = 16 d) and long-term (T1/2 = 78 d) physiological exchanges and two excretion pathways: urine and feces. To validate the model, the predicted excretion and absorption of cholesterol was compared with that described in the literature. The radiometric doses were calculated in function of the phantom body mass (M) applying MIRD (medical internal radiation dose) protocol with ANACOMP software. The effective dose coefficients for oral administration were: 2.93×10–10 Sv.Bq–1 (73.3 kg); 3.84×10–10 Sv.Bq–1 (56.8 kg); 6.74 × 10–10 Sv.Bq–1 (33.2 kg) and 7.72 × 10–10 Sv.Bq–1 (19.8 kg). To determinate the dose for intermediate body mass M the polynomial interpolation can be used: Sv.Bq–1 (kg) = 6 × 10–15M3 – 8 × 10–13M2 + 2 × 10–11M + 6 × 10–10 (R2 ≅ 1). In the same way, for intravenous administration were: 3.72 × 10–10 Sv.Bq–1 (73.3 kg); 4.87 × 10–10 Sv.Bq–1 (56.8 kg); 8.49 × 10–10 Sv.Bq–1 (33.2 kg); 1.26 × 10–9 Sv.Bq–1 (19.8 kg). Similarly, for any M body mass: Sv.Bq–1 (kg) = –4 × 10–15M3 + 9 × 10–13M2 – 7 × 10–11M + 2 × 10–9 can be used.