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Experimental study on fatigue mechanical properties of sandstone after dry and wet cycle

Jin-Song Zhang, Yu Lu, Heng-Liang Zhang, Yu-Di Yang, Yi-Shun Bu

Archives of Civil Engineering

2022

Vol. 68, nr 4

377--387

At present, many studies have been carried out on the fatigue mechanical properties of conventional rocks, but there are few studies on the mechanical properties of rocks after water rock interaction. The aim is to better study the fatigue mechanical characteristics of sandstone after dry wet cycle and the research object we take was sandstone samples after a certain number of drying and wetting cycles. The WAW-2000 electro-hydraulic servo pressure system was used to carry out uniaxial fatigue cyclic loading and unloading tests with different amplitudes and different upper limit stresses. The test found that: when the sample is damaged under fatigue load, the stress-strain curve shows a sharp downward trend and a sudden instability failure occurred in the sample. With the increase of the upper limit stress and amplitude, the life of the sample decreases gradually which also conforms to the change of power function. Then the relationship between fatigue life and stress is obtained. The fatigue stress-strain curve is characterized by sparse-dense-sparse. With the increase of cycle time, the axial strain of the sample shows an inverted “S” shape. The strain change can be divided into three stages: initial stage, constant velocity stage and acceleration stage.

A rapid and sensitive High-Performance Liquid Chromatography-tandem Mass Spectrometry method for determining apremilast in beagle dog plasma and urine: Application in a pharmacokinetic study

Yan Genquan, Yu Lu, Chen Xu, Tran Triet, Nguyen Lam, Zhijun Wang, Wang Ling

Acta Chromatographica

2021

Vol. 33, no. 2

112--119

A rapid and sensitive High-Performance Liquid Chromatography-tandem Mass Spectrometry (HPLC/MS/MS) method for determining apremilast in beagle dog plasma and urine samples was developed and validated using clopidogrel as the internal standard (IS). Apremilast was extracted from the plasma and urine samples by liquid–liquid extraction using methyl tert-butyl ether. Chromatographic separation was performed using a C8 column with gradient elution and a mobile phase containing methanol and 0.1% formic acid. Quantification was achieved in multiple reaction monitoring (MRM) mode with a transition of m/z 461.3→178.2 for apremilast and m/z 322.2→184.1 for clopidogrel (IS). This method was validated regarding its specificity, linearity, precision, accuracy, and stability. The lower limit of quantification (LLOQ) for this method was 5 ng/mL, and the calibration curve was linear over 5–1,000 ng/mL. The intra- and inter-run coefficients of variance (CV) of aprelimast in plasma samples were less than 12.92% and 10.64%, respectively, while in urine samples, the CV were less than 11.84% and 10.20%, respectively. The samples were stable under the tested conditions. This method was successfully applied to a pharmacokinetic study in beagle dogs following oral administration of 10 mg of apremilast.