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Photocatalysis combined with chromatographic methods as a new promising tool in drug metabolism studies – a review

Gawlik M., Skibiński R., Trawiński J., Komsta Ł.

Acta Chromatographica

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2018

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Vol. 30, no. 1

1--8

EN

The number of new drugs launched to the market is constantly increasing; however, the metabolism of many of them is still not fully established. The knowledge of drug metabolism pathways is crucial for the efficacy and safety of therapies and, in classical approach, requires the use of animals as well as human volunteers, but this kind of research is expensive and time-consuming. Therefore, nowadays, more and more biological and chemical in vitro methods are developed for the drug metabolism study. This review is focused on the photocatalytic degradation of chemicals and the application of this process in chromatographic methods of drug metabolism research. A theoretical background of photocatalysis and all its applications in a drug metabolism study were reviewed, and other in vitro methods that are actually used were summarized and discussed. Other analytical methods used in this area were also discussed and compared.

2

Comparison of ESI and APCI sources in Q-TOF mass spectrometer in photodegradation study of selected psychotropic drugs

Trawiński J., Skibiński R., Komsta Ł.

Acta Chromatographica

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2017

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Vol. 29, no. 2

161--172

EN

Ultra high-performance liquid chromatography (UHPLC) coupled with high-resolution quadrupole time-of-flight (Q-TOF) mass spectrometry was used for the preliminary photodegradation study of nine new generation psychotropic drugs. Based on the above method, two ionization sample modes — electrospray and atmospheric pressure chemical ionization were used for the registration of photodegradation profiles of the selected drugs. Multivariate chemometric analysis showed that electrospray ionization (ESI) method is more specific than atmospheric pressure chemical ionization (APCI) in high-resolution mass spectrometry (HR-MS) analysis of the analyzed psychotropic drugs. It was noticed that, with the use of ESI method, more potential photodegradation products can be identified and lower limits of its detection can be obtained.

3

Zmiany jakości wody w Strudze Dormowskiej w ciągu kilkudziesięciu lat na podstawie analizy wskaźników i indeksów biologicznych

Graczyk L., Golski J., Trawiński J., Andrzejewski W., Mazurkiewicz J.

Woda-Środowisko-Obszary Wiejskie

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2016

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T. 16, z. 2

37--48

PL

Celem przedstawionych badań było określenie stanu ekologicznego Strugi Dormowskiej na podstawie struktury jakościowej i ilościowej bentosu oraz ichtiofauny, a także porównanie wyników otrzymanych na bazie wskaźników i indeksów biologicznych w ciągu kilkudziesięciu lat. Warunki środowiskowe cieku na odcinkach wytypowanych do badań różniły się między sobą pod względem morfometrii koryta, substratu dennego, temperatury i zawartości tlenu, a także wartości wskaźników i indeksów biologicznych. Na podstawie przeprowadzonych badań należy przyjąć, że wody Strugi Dormowskiej kwalifikują się do trzeciej klasy jakości wód. Niewątpliwy wpływ na stan ekologiczny rozpatrywanego cieku ma położenie zlewni, która obejmuje głównie obszary o charakterze rolniczym. Rzeka przepływa także przez tereny o wysokim potencjale turystyczno-rekreacyjnym, co może oddziaływać na strukturę jakościową i ilościową organizmów wskaźnikowych.

EN

The aim of this study was to determine the ecological status of Struga Dormowska stream, based on qualitative and quantitative structure of benthic macroinvertebrates and ichthyofauna. The obtained results were compared to other studies, conducted for several decades. Based on the environmental conditions, research sites were varied due to riverbed morphometry, bottom substrate, temperature, dissolved oxygen and values of biological indicators and indices. Based on the obtained results, Struga Dormowska stream represent a third, sufficient class of water quality. The undoubted impact on ecological status of Struga Dormowska stream, has a location of catchment, which mainly covers the agricultural areas. The river also flows through areas with high potential for tourism and recreation, which may affect the species composition of benthic macroinvertebrates and fish.

4

Habitat variability and fish species structure in the Kończak stream

Golski J., Przybył A., Mazurkiewicz J., Andrzejewski W., Trawiński J.

Oceanological and Hydrobiological Studies

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2010

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Vol. 39, No.4

83-98

EN

In the year 2008, studies on ichthyofauna were carried out in the Kończak stream. The stream was divided into four sections representing the variability of the water course. In each section, a research segment (100–150 meters long) was defined. In the ichthyofauna structure analysis, the indices of quantitative biocenotic domination and biomass were used. Furthermore, on the basis of the obtained data, the Shannon-Wiener indices of species diversity (H), as well as the abundance and the biomass (ABC index) were calculated. Altogether, in all research localities, 667 fish specimens were collected, with a total weight of 8,760 g and classified into 19 species. The caught fish were classified into 8 reproductive groups. Significant differences in the species composition and the number of fish were recorded between the particular sections. The number of species occurring in the studied sections oscillated between 2 and 17. The richest ichthyocenoses were recorded in the transitional and forest sections characterized by a comparatively small transformation of the habitats and good environmental conditions. In the remaining two sections, located in the middle and in the upper stream course, there was a distinct impoverishment of ichthyocenoses caused by the decreased attractiveness of the habitats.

5

W kierunku społeczeństwa informacyjnego

Trawiński J.

Przegląd Komunalny

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2006

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nr 11

127-127

PL

Z ekspertyzy pt. "Cele i kierunki rozwoju społeczeństwa informacyjnego w Polsce", przygotowanej na zlecenie Komitetu Badań Naukowych w 2000 r., wynika, że budowa nowych, szerokopasmowych sieci magistralnych jest obecnie ekonomicznie uzasadniona tylko jako element składowy większych inwestycji infrastrukturalnych.