Wyniki wyszukiwania - BazTech

1

Synthesis and evaluation of novel mri contrast agents of chemically modified GD-DTPA complexes with sugars

Sugiyama M., Yamashita M., Yu G., Fujie M., Ogawa K., Ozaki N., Aoki T., Mizuno S., Okada S., Tachi K., Aoshima K., Sankar U. R., Kumar B. S., Takehara Y., Sakahara H.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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Vol. 3, No. 4

191-194

EN

MRI is one of medical diagnostic imaging technologies that can draw the cross section in the body. To obtain a clearer image, Gd complexes are often used as MRI contrast agents. Gd-DTPA (Gd-Diethylenetriaminepentaacetate, Magnevist registered trademark ) is used in particular as the MRI contrast agents. We prepared and evaluated novel MRI contrast agents that were chemically modified Gd-DTPA with sugars (represented as Gd-DTPA-Sugar) via hydrolysis route for providing specificity to target organs and tissues. Gd-DTPASugar complex showed an excellent potential for the MRI contrast agent (r1=31.2 s-1mM-1). Gd-DTPA-Sugar complexes alternatively prepared by shorter synthetic route without protection/ deprotection (hydrolysis) method showed inferior results (r1=6.3 and 8.1 s-1mM-1) to the hydlized product.

2

R&D of novel medicinal materials for curing cancer: sugar modified Gd-DTPA MRI contrast agents and phospha sugar anti-cancer agents

Yamashita Y., Yamashita M., Fujie M., Suyama K. A. T., Ito S., Reddy V. K., Yamada M., Ogawa K., Ozaki N., Nakamura S., Aoki T., Yu G., Aoshima K., Kato T., Kamikage N., Kiyofuji K., Takehara Y., Sakahara H., Takayanagi H., Oshikawa T., Laurent S., Burtea C., Van der Elst L., Muller R. N.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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Vol. 3, No. 4

80-83

EN

Novel Sugar Dendritic Gd-DTPA Complexes for MRI Contrast Agents were prepared and evaluated by in vitro and in vivo methods. The sugar dendritic MRI contrast agents have a good blood vesse pool character, and draw blood vessels and liver cancer remarkably clearer than the clinically using Gd-DTPA. Phospha sugar derivatives or phosphorus heterocyclic derivatives provided by functional groups such as epoxide, bromide, etc., were prepared and evaluated by MTT in vitro method. These phospha sugar derivatives showed excellent activities against leukemia cells as well as solid cancer cells in fashions of (i) higher activity, (ii) wider spectra, (iii) higher selectivity and specificity distingushing healthy and cancer cells, etc., compared with the molecular targeting chemotheraputic anti-cancer agent, Gleevec.

3

Quintet-gated FEA to form crossover beam

Tagami T., Takeda M., Horie S., Yoshida T., Nagao M., Neo Y., Aoki T., Mimura H., Kanemaru S.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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Vol. 3, No. 4

157-158

EN

In this report, we have described about new field emission array (FEA) structure built-in micro-column. This newly proposed FEA has multi-gated structured and is designed to form a crossover. We had already demonstrated the quad- and quintet- gated FEA. A crossover formation by was successfully observed for the first time. by the quintetgated FEA Furthermore electron beam lithography was demonstrated.

4

Introduction of three-dimensional measurement technologies developed and applied in suzuki motor corporation

Yamage Y., Aoki T., Hashimoto T., Rövid A., Shibahara T., Akatsuka S., Suzuki H., Takeshi M., Ono M.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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Vol. 3, No. 4

220-223

EN

Suzuki Motor Corporation (SMC) recognizes the importance of collaborative projects with Universities and how it contributes to technological development effectively. In spite of the world economical depression, several projects could get started this year leaded by SMC. As a researcher of SMC, Author takes charge of two collaborative projects and introduces these as typical examples of the most successful collaborations. The first is, "3D Measurement System for Crash Tested Car" at Shizuoka University (Japan) and Budapest Tech Polytechnical Institute (Hungary) from 2008; the second is, "High-Accuracy Stereo Vision System Based on Phase-Only Correlation (POC) and Its Application to metal Component Inspection" with Tohoku Univ. (Japan) 2003-2005. By these collaborations, the profound knowledge of universities has a lot of possibility to suits the technical needs of SMC.

5

High speed signal processing for photon counting X-ray detection

Shinomiya B., Koike A., Morii H., Okunoyama T., Neo Y., Mimura H., Aoki T.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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Vol. 3, No. 4

143-146

EN

Recently practical X-ray measurement systems are demanded energy distinction function. Photon-counting CdTe semiconductor detectors have a high energy resolution in a low count rate condition at room temperature. However, the energy resolution is decreased by pile-up phenomenon in a high count rate condition. In conventional signal processing, processing time estimated X-ray photon energy from the pulse waveform is about tens of microseconds. This time is depended on the pulse decay time. This paper purposes to maintain the high energy resolution by changing the signal-processing algorithm, which derived the pulse rise height of the output waveform from the CdTe detector in a high count rate condition. As a result, the pulse rise time required to estimate the pulse rise height was short about 100 ns at incident X-ray energy 60 keV. As the result of energy spectrum by using this data, the FWHM of about 11keV (at 60 keV) when the count rate of 500 kcps. This result shows the possibility that the photon counting sensor has application for the high count rate imaging without decrease of the high energy resolution.

6

Growth and application of ultra-long multi-walled carbon nanotube

Shimizu S., Okada M., Inoue Y., Neo Y., Kume H., Aoki T., Mimura H.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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Vol. 3, No. 4

163-165

EN

We found the easy and efficient synthesis method of the vertically aligned ultralong multi-walled nanotubes using iron chloride powder. The 2.1-mm-long bulk nanotubes can be grown by conventional thermal chemical vapor deposition on bare quartz surface with the single gas flow of acetylene for 20 min. In addition to the high growth rate, the bulk of carbon nanotubes is easily spun into the yarn by pulling it out, and the present method also provides the coating ability with nanotubes as a new functionality of this nanomaterial. Š 2008 American Institute of Physics.

7

Dynamics of laser-induced melting and modification of the surface of semiconductors by nanosecond laser pulses

Gnatyuk V., Aoki T., Vlasenko O., Gorodnychenko O.

Journal of Automation Mobile Robotics and Intelligent Systems

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2009

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Vol. 3, No. 4

33-36

EN

In situ detection and dynamics of laser-induced melting in different semiconductor crystals (CdTe, CdHgTe, GaAs, InSb and SiC) were performed by the time-resolved reflectivity (TRR). The samples were subjected to irradiation with 20 ns pulses of KrF excimer or ruby laser with energy density varied in a wide range. The surface morphology of the crystals was monitored using optical microscopy and time dependences of the temperature of the crystal surface as a function of laser pulse energy density was also calculated. The melting and ablation threshold values were determined and specific features of the laser-induced phase transitions in the surface region of the semiconductors were analyzed.

8

Wear resistance of experimental Ti-Cu alloys

Ohkubo C., Shimura I., Aoki T., Hanatani S., Hosoi T., Hattori M., Oda Y., Okabe T.

International Journal of Applied Mechanics and Engineering

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2002

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Vol. 7, Spec. is

409-414

EN

After using cast titanium prostheses in clinical dental practice, severe wear of titanium teeth has been observed. This in vitro study evaluated the wear behavior of teeth made with several cast titanium alloys containing copper (CP Ti + 3.0wt% Cu; CP Ti + 5.0wt% Cu; Ti-6Al-4V + 1.0wt% Cu; Ti-6Al-4V + 4.0wt% Cu) and compared the results with those for commercially pure (CP) titanium, Ti-6Al-4V, and gold alloy. Wear testing was performed by repeatedly grinding upper and lower teeth under flowing water in an experimental testing apparatus. Wear resistance was assessed as volume loss (mm3) at 5kgf (grinding force) after 50,000 strokes. Greater wear was found for the six types of titanium than for the gold alloy. The wear resistance of the experimental CP Ti + Cu and Ti-6Al-4V + Cu alloys was better than that of CP titanium and Ti-6Al-4V, respectively. Although the gold alloy had the best wear property, the 4% Cu in Ti-6Al-4V alloy exhibited the best results among the titanium metals. Alloying with copper, which introduced the ?Ti/Ti2Cu eutectoid, seemed to improve the wear resistance.