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2 2024

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Individual dosimetry and monitoring response to treatment in tandem PRRT with [177Lu/90Y]-DOTA-TATE

Kacperski Krzysztof, Budzyńska Anna, Kubik Agata, Pastusiak Patrycja, Chalewska Wioletta, Lenda-Tracz Wioletta, Borkowska Anna, Walecka-Mazur Agata, Szczodry Artur, Braziewicz Janusz, Kołodziej Maciej, Kamiński Grzegorz, Dedecjus Marek, Długosińska Joanna, Januszkiewicz-Caulier Joanna, Hubalewska-Dydejczyk Alicja, Opalińska Marta, Kowalska Aldona, Mikołajczak Renata

Polish Journal of Medical Physics and Engineering

2024

Vol. 30, Iss. 4

294--299

Introduction: The Duonen project aims to test the efficacy of tandem PRRT therapy of neuroendocrine tumors with DOTA-TATE labeled with 177Lu and 90Y radionuclides compared to conventional mono-radionuclide therapy using 177Lu with a fixed activity of 7.4 GBq. The paper presents the dosimetric procedure used and preliminary results obtained from the treatment of 40 patients and 113 cycles of therapy. Material and Methods: Dosimetry is performed using the QDose program based on 4 SPECT/CT scans and 5 blood samples taken for bone marrow dosimetry. Calculation of the dose to the kidneys is done by segmenting them on images, fitting the corresponding activity versus time (TAC) curves and calculating the dose using the Voxel-S method. The dose to the red marrow is calculated based on the IDAC2 model using the TAC curve for blood obtained from the measurements (self-dose) and the segmented organs from images (cross-dose). In addition, the time-integrated activity coefficients of activity in selected tumors or high uptake areas in four consecutive cycles of therapy were calculated for several patients as a measure of response to therapy. Results: Large variability of individual doses to kidneys is observed. The average specific dose for 177Lu was equal to 0.76 Gy/GBq, SD = 0.29 Gy/GBq, and for 90Y: 3.26 Gy/GBq, SD = 1.26 Gy/GBq. With the standard activity equal to 7.4 GBq in the first cycle, the activity in the next cycle could be increased by > 10% in 60% of cases and had to be decreased in 16% of cases. Conclusion: Individual dosimetry is an important part of PRRT, leading to significant dose modifications in subsequent cycles in more than 80% of the cases studied.

Effect of ‘Regent’ grapevine rootstock type on energy potential parameters

Klimek Kamila E., Kapłan Magdalena, Maj Grzegorz, Borkowska Anna, Słowik Tomasz

Journal of Water and Land Development

2024

no. 62

50--56

The paper presents the possibilities of energy management of residues from the production of ‘Regent’ grapevines. Field tests were conducted under conditions of temperate climate in 2022 on six types of rootstocks viz: 101-14, 125 AA, 161-49, 5 BB, SO4, SORI, the control were ungrafted vines growing on their own roots. The study analysed the following crop parameters, i.e. number and mass of grapes, number and mass of berries; quality parameters of woody shoots. Technical and elemental analysis was performed, and the heat of combustion and calorific value were determined to define fuel quality parameters. In addition, emission factors of CO, CO2, SO2, NOx and ash were estimated to demonstrate the degree of impact of potential bio-residue from the combustion process. An assessment was made on the basis of stoichiometric equations of flue gas composition, as well as theoretical oxygen demand and total fuel gas volume. The study showed that cultivation on 125 AA rootstock is characterised by obtaining significantly the highest yield, shoot mass and bio-residues suitability for energy purposes. The research showed that the most effective in practical cultivation is the use of SORI and SO4 rootstocks in cultivation, which are characterised by average parameters of obtained yield, growth value and fuel.