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Manufacturing of substitutes for spongy bone with increased absorbability

Budnicka Monika, Gadomska-Gajadhur Agnieszka, Ruśkowski Paweł

Chemical and Process Engineering

2019

Vol. 40, nr 4

411-–423

Composite scaffolds with increased hydrophilicity were prepared for cancellous bone regeneration by the freeze-extraction method. As a construction material, a poly–L–lactide (PLLA) was applied. As a hydrophilic, modifying agent a methacrylic acid copolymer, trade name Eudragit, was used. Apreliminary investigation and optimization of the processwere performed. For the obtained scaffolds, regression equations determining the effect of: EudragitE100/PLLA weight ratio; volume ratio of methanol (porophore)/PLLA solution in dioxane on interconnected porosity and mass absorbability of obtained implants were calculated.