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Impact of sintering temperature of hydroxyapatite on biological and physicochemical properties of alginate/HA biomaterials for regenerative medicine applications

Kazimierczak P., Syta E., Sochan J., Ginalska G., Przekora A.

Engineering of Biomaterials

2018

Vol. 21, no. 145

16--19

Synthetic hydroxyapatite (HA) has gained considerable attention in regenerative medicine over recent decades. It is widely used as a bone filler and constituent of various biomaterials. HA possesses high biocompatibility, osteoconductivity, bioactivity, and bioresorbability. There are many different synthesis methods for HA described in the available literature. It is worth noticing that even slight changes in pH, reaction conditions or chemical composition during synthesis, can influence biological, physicochemical, and mechanical properties of resultant HA. The aim of this study was to evaluate the impact of sintering temperature of hydroxyapatite on biological and physicochemical properties of biomaterial made of alginate and hydroxyapatite granules. Alginate/HA material was produced using HA sintered at temperature of 800oC and HA sintered at temperature of 1150oC. Microstructure of the fabricated biomaterials was visualized by SEM. Osteoblast growth on the composites was assessed using human foetal osteoblast cell line. Moreover, ion reactivity, plasma/serum protein adsorption ability as well as water/NaCl uptake capability of the biomaterials were compared. Obtained results demonstrated that although both biomaterials had the same chemical composition, composite comprising hydroxyapatite sintered at temperature of 1150oC had smoother surface, revealed lower ion reactivity, was more favourable to osteoblast growth, and adsorbed lower amount of fibrinogen (which is known to promote biomaterial-induced inflammatory response), compared to the material made of hydroxyapatite sintered at temperature of 800oC. Thus, the type of bioceramics used for the production of biomaterials should be tailored to their specific applications – bone fillers for primarily in vivo implantation or in vitro cell-seeded scaffolds.