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1 International Journal of Applied Mechanics and Engineering

1 2003

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Rheological changes in rat blood as a result of photodynamic treatment

Shulman Z. P., Makhaniok A. A., Vilanskaya S. V., Zhavrid E. A., Istomin Y. P., Sheleg S. V.

International Journal of Applied Mechanics and Engineering

2003

Vol. 8, no spec.

307-312

The purpose of this study was experimental investigation of hemorheological changes under photodynamic therapy. The experiments were conducted on laboratory white purebred male rats under narcosis. Chlorin e6 as photosensitizer (PS) was used. Photodynamic exposure (PDE) was performed with semiconductor laser (wave length 670nm). The irradiated area was , and light exposure dose E was 22.5 to . Blood was sampled 1 hour after PDE completion and was heparin-conserved. The experimental study of PDE effect on the rheological properties of blood of tumour-free rats revealed that chlorin at a dose of body mass caused a significant increase in the hematocrit H. The flow curves were adequately described by the power law rheological model with independent of H and E. The correction to the parameter of blood consistency K in rats not exposed to PDE assumed the form . The exposure of rat skin to light at E 22.5 to resulted in an increase in the consistency parameter. The flow curves taking into account PDE are adequately described by the model . The results obtained from this study indicate that PDE at a concentrated chlorin dose of and light exposure dose of 22.5 to produces a significant increase in rat blood non-newtonian viscosity.