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Bis(2-amidophenyl) Diselenides Derived from Amino Acids and Dipeptides: Synthesis, Antiviral and Antimicrobial Activity

Palus J., Dąbrowska E., Piętka-Ottlik M., Piasecki E., Młochowski J.

Polish Journal of Chemistry

2008

Vol. 82, nr 5

1015-1022

Synthesis of bis(2-aminophenyl) diselenide 1 derivatives, having amino acids and dipeptides moieties, has been reported. This process has been realized by acylation of both amine groups in 1 us ing N-Boc blocked amino acids 8 in the presence of DCC and HOBT, followed by deprotection to hydrochlorides 9. The free amines 2 have been obtained by removing the protective groups. In the similar way dipeptides 3, 10 and 11 have been prepared. Selected compounds have been tested as potential antiviral, antibacterial and antifungial agents.