Wyniki wyszukiwania - BazTech

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Ion Move Brownian Dynamics (IMBD) : Simulations of Ion Transport

Kurczyńska M., Kotulska M.

Acta of Bioengineering and Biomechanics

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2014

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Vol. 16, no. 4

107--115

EN

Purpose: Comparison of the computed characteristics and physiological measurement of ion transport through transmembrane proteins could be a useful method to assess the quality of protein structures. Simulations of ion transport should be detailed but also time-efficient. Methods: The most accurate method could be Molecular Dynamics (MD), which is very time-consuming, hence is not used for this purpose. The model which includes ion-ion interactions and reduces the simulation time by excluding water, protein and lipid molecules is Brownian Dynamics (BD). In this paper a new computer program for BD simulation of the ion transport is presented. We evaluate two methods for calculating the pore accessibility (round and irregular shape) and two representations of ion sizes (van der Waals diameter and one voxel). Results: Ion Move Brownian Dynamics (IMBD) was tested with two nanopores: alpha-hemolysin and potassium channel KcsA. In both cases during the simulation an ion passed through the pore in less than 32 ns. Although two types of ions were in solution (potassium and chloride), only ions which agreed with the selectivity properties of the channels passed through the pores. Conclusions: IMBD is a new tool for the ion transport modelling, which can be used in the simulations of wide and narrow pores.

2

Problems with hardly biodegradable contaminants in tannery wastewater treatment

Ozonek J., Kotulska M., Piotrowicz A.

Polish Journal of Chemical Technology

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2006

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Vol. 8, nr 3

125-128

EN

The main purpose of this study was to present the application of biological fixed bed reactor in the tannery wastewater treating. Raw tannery sewages are characterized by a great concentration of ammonia nitrogen, total suspended solids (TSS), total dissolved solids (TDS) and the presence of sulphide and chromium. The chemical pretreatment does not solve the problem because it removes only part of the biological oxygen demand (BOD) and the chemical oxygen demand (COD) (65 - 85%), suspended solids, sulphide and chromium. Due to the insufficient effectiveness of the mechanical and chemical methods, a biological method has been developed. Therefore the fixed bed reactor with Terrapol®-type filling packs was used. Its operational volume of 537 m3 was divided into the denitrification chamber, nitrification chamber with the fixed bed and the multi-streams secondary settling chamber. The experimentation comprised 2 stages. The first one was carried out in the full scale during the technological starting-up of the Szczakowa tannery wastewater plant (Jaworzno, Poland), while the other one concerned some improvements of the method. With the additional use of active carbon and polyelectrolyte, the proposed biological treatment has proved its effectiveness and suitability for tannery wastewater purification.

3

Oczyszczenie ścieków garbarskich na biologicznym złożu zanurzonym

Kotulska M., Ozonek J.

Gaz, Woda i Technika Sanitarna

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2005

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Nr 12

29-33

EN

Characteristics of sewage management in tanneries. Reactor research in technical scale. Technological diagram of a modernized biological sewage treatment plant. Attempts to optimize bioreactor's working.

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1/f ɑ noise in nanopores and its potential application in biosensors

Kotulska M.

Elektronika : konstrukcje, technologie, zastosowania

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2004

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Vol. 45, nr 8-9

130-132

EN

Pores of nanometer size created in a non-conducting membrane are considered as a new potential molecular sensor, which could be used for detection and characterization of single biomolecules. Especially biosensors for DNA detection and sequencing are in quest. The idea of molecular detection is based on the measurement of translocation time when a biomolecule is moving through the pore. This method could be extended with another approach - analysis of the nanopore slochastic characteristics, more appropriate for smaller molecules that do not block the pore.

PL

Pory o średnicy pojedynczych nanometrów, generowane w nie przewodzącej membranie, mogą być potencjalnie wykorzystane jako czujniki molekularne rozpoznające obecność i strukturę pojedynczych biomolekuł. Poszukiwane są zwłaszcza czujniki umożliwiające rozpoznawanie i sekwencjonowanie DNA. Najczęściej rozważane jest rozpoznawanie molekuł w oparciu o czas translokacji przez por. Metoda ta może być rozszerzona o analizę charakterystyki stochastycznej nanopora, która może dostarczyć więcej informacji w przypadku cząsteczek mniejszych, nie blokujących pora.

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Komputerowa analiza matematycznego modelu dielektrycznej dyspersji w tkance

Kotulska M.

Acta Bio-Optica et Informatica Medica. Inżynieria Biomedyczna

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1998

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Vol. 4, nr 2

57-62

PL

Praca poświęcona jest własnościom dielektrycznym tkanki w obszarze dyspersji α. Przedstawiony został model teoretyczny zjawiska odpowiedzialnego za obserwowany tu przebieg charakterystyki, którą cechuje występowanie dyspersji anomalnej. Przeprowadzone zostały symulacje komputerowe, które potwierdzają wyniki rozważań teoretycznych. W pracy wskazano też na możliwości zastosowania odpowiedzi dielektrycznej tkanki w diagnostyce medycznej.

EN

Dielectric properties of tissue in the region α are analysed. It is introduced a theoretical model of the phenomenon underlying the characteristics with anomalous dispersion. The analysis is supported by computer simulations, which confirm the theoretical results. Also, an application of tissue dielectric characteristics in medical diagnostics is indicated.