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2 Polish Journal of Chemistry

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Statherin SV2 and Its Analogue. Synthesis and Evaluation of Antimicrobial Activity

Kamysz W., Kochańska B., Kędzia A., Ochocińska J., Maćkiewicz Z., Kupryszewski G.

Polish Journal of Chemistry

2002

Vol. 76 / nr 6

801-806

Statherins are natural peptides derived from human saliva. They may take part in transport of calcium and phosphate and most probably are partly responsible for protection and recalcification of tooth enamel. The solid phase synthesis of statherin SV2 and its dephosphorylated analogue, their purification by solid phase extraction (SPE), as well as the evaluation of their antibacterial activity are presented.

Statherin and its shortened analogues

Wojciechowska I., Kochańska B., Stelmańska E., Knap N., Maćkiewicz Z., Kupryszewski G.

Polish Journal of Chemistry

1998

Vol. 72, nr 9

2098-2102

Statherin is a 43-amino acid residue phosphominiprotein present in human parotid and submandibular saliva. It may take part in transport of calcium and phosphate and most probably is partly responsible for the protection and recalcification of tooth enamel. The solid phase synthesis of statherin and its three shorttened analoques: (1-15)statherin, [Ser(2), Ser(3)](1-15) statherin and [Asp(2), Asp(3)](1-15) statherin is presented. It was established that polyclonal antibodies directed against three shortened analoques showed affinity to synthetic statherin and statherin in saliva.