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Chemical Structure of the Salmonella Anatum (O:3,10) O-antigen

Gajdus J., Kaczyński Z., Czerwicka M., Dziadziuszko H., Szafranek J.

Polish Journal of Chemistry

2008

Vol. 82, nr 7

1393-1393

An O-specific polysaccharide containing D-galactose, D-mannose and L-rhamnose was obtained by mild acid hydrolysis of the lipopolysaccharide of the Salmonella Anatum bacterium. The structure of the polymeric O-antigen was studied by composition analysis and by 1D and 2D, 1H and 13C NMR spectroscopy. The repeating unit of the polymer was identified as a linear trisaccharide with the structure shown below, in which the galactose residue was partially O-ac ety lat ed at C-6; this was re spon si ble for the mol e cule’s structural heterogeneity. → 3)-D-Galp-(1𔾺)-D-Manp-(1𔾸)-alfa-L-Rhap-(1→ 6 OAc (75%).

Structure of the Polysaccharide O-Antigen of Salmonella Aberdeen (O : 11)

Szafranek J., Kaczyńska M., Kaczyński Z., Gajdus J., Czerwicka M., Dziadziuszko H., Głośnicka R.

Polish Journal of Chemistry

2003

Vol. 77 / nr 9

1135-1140

O-specific polysaccharide (OPS) of Salmonella Aberdeen was obtained from bacterial cell mass by water-phenol extraction procedure of lipopolysaccharide (LPS) followed by its mild acid hydrolysis and gel filtration of soluble carbohydrate material. Rhamnose, galactose, N-acetyl-glucosamine and mannose were detected and their linkages were established. Sugar configurations, D or L, were determined for (S)-(+)-2-butyl glycosides on an achiral capillary column. The structure of OPS was determined by analysis of spectra of 1H and 13C NMR and homonuclear and heteronuclear correlations spectra. Anomeric configurations were tentatively assigned by chromium trioxide oxidation and later proved by anomeric proton chemical shifts, H1-H2 coupling constants and proton coupled 13C spectra. Sugar sequences were established from comparisons of specific carbon shifts with those from literature, two-dimensional nuclear Overhauser effect spectroscopy (NOESY) and heteronuclear multiple-bond correlation experiments (HMBC). The repeating unit of S. Aberdeen OPS has the structure: _3)-_-D-GlcpNAc-(1_3)-[ _-D-Manp-(1_4)-]_-D-Galp-(1_4)-_-L-Rhap-(1_

Enantiomers of Hepatitis B Virus (HBV) Surface Antigen (140-146) S Region Fragment : Synthesis and Studies on Immunological Properties

Kunikowska D., Dera-Tomaszewska B., Dziadziuszko H., Wysocki J., Wolańska I., Maćkiewicz A., Głosnicka R., Kupryszewski G.

Polish Journal of Chemistry

1999

Vol. 73, nr 11

1803-1809

Synthesis of hepatitic C virus protein fragments and evaluation of their immunogenicity

Karawajczyk B., Maćkiewicz Z., Kunikowska D., Dziadziuszko H., Dera-Tomaszewska B., Głośnicka R., Kupryszewski G.

Polish Journal of Chemistry

1998

Vol. 72, nr 1

84-88

Three polypeptide fragments of Hepatitis C virus protein (130-140)C, (133-142)C and (1406-1415)NS3 were synthesized using the solid-phase method. The immunogenicity of the peptides was tested on rabbits. All the peptides studied revealed homoral and cell response.