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A comparison of selected dosimetric parameters of two Hodgkin Lymphoma radiotherapy techniques with reference to potential risk of radiation induced heart disease

Alibeyki E., Karimkhani S., Saadatmand S., Shokrani P.

Polish Journal of Medical Physics and Engineering

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2018

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Vol. 24, Iss. 3

121--126

EN

Purpose: Hodgkin lymphoma (HL) is one of the most frequent malignancies among pediatric patients. One of the common causes of death in HL survivors after radiation therapy (RT), is radiation-induced heart disease (RIHD). The aim of this study was to compare several dosimetric parameters for two methods of early stage Hodgkin lymphoma radiotherapy with reference to potential risk of RIHD. Materials and Methods: Using a series of computed tomography slices of 40 young patients, treatment planning was done in two methods of HL RT, including involved field (IFRT) and involved site (ISRT) in doses of 20, 30, and 35 Gy. Contouring of clinical target volume as well as the organs at risk, including the heart, was performed by a radiation oncologist. The mean and maximum dose of heart (Dheart-mean and Dheart-max), the volume of heart receiving a dose more than 25 Gy (V25), and the standard deviation of dose as a dose homogeneity index in heart, were used to compare the RIHD risk. Results: The mean value for Dheart-mean in ISRT method in all doses was less compare to IFRT. Maximum reduction in mean value of Dheart-mean occurred at moving from 30 Gy IFRT to ISRT by 9.53 Gy (p < 0.001) and minimum was between 35 Gy IFRT and ISRT. The mean value for Dheart-max was fewer in IFRT rather than ISRT and the maximum difference was between 35 Gy IFRT and ISRT (1.35 Gy). The mean of V25 of heart was 26.66% and 23.74% in 35 Gy IFRT and ISRT, respectively, and dose distribution was more homogeneous in IFRT. Conclusions: If Dheart-max and V25 of heart or homogeneity of dose distribution in heart are considered as determining factors in RIHD, then IFRT can be considered optimum, especially in 35 Gy IFRT; while, assuming the Dheart-mean as the most important factor in RIHD, superiority of ISRT over IFRT is observed.

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An intraoral cone system for a Neptun 10PC linear accelerator

Shokrani P., Soltani P.

Nukleonika

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2011

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Vol. 56, No. 4

381-384

EN

Intraoral irradiation, the treatment choice for well defined oral-cavity tumors, is done using intraoral cone (IOC) systems. In this study, an IOC system was developed for a Neptun 10PC linac. Beam parameters necessary to plan an intraoral electron treatment were evaluated for two applicators, a flat and a beveled end. Measurements were performed using a Scanditronix (p-Si) diode field detector in a Scanditronix (RFAplus) 3-D (three-dimensional) water phantom. Percent depth dose distributions, beam profiles, and leakage dose distributions for the developed cone system are presented.

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Determination of the geometry function for a brachytherapy seed, comparing MCNP results with TG-43U1 analytical approximations

Raisali G., Ghonchehnazi M. G., Shokrani P., Sadeghi M.

Nukleonika

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2008

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Vol. 53, No. 2

45-49

EN

Geometry function is the only dosimetry parameter of a brachytherapy source seed, introduced in TG-43U1 protocol which is determined using calculational methods rather than physical measurement. In order to evaluate the accuracy of point and line source approximations, for calculation of the geometry function, the MCNP computer code has been used for a typical brachytherapy seed and the results have been compared. The MCNP has been used to simulate the geometry and activity distribution of a Pd-103 seed in order to calculate the geometry function for various angles and distances from the source. The comparison of results shows that at distances close to the source, the values predicted with different methods are not in agreement. The difference between the MCNP calculations and line approximation for small angles from ? = 0 to 15° is about 27% at 0.25 cm from the seed center. This difference is so much higher for point source approximation (up to a factor of 3) even up to distances of 0.5 cm from the source. As ? increases, the difference between MCNP and approximate methods is reduced. Therefore, for small distances from brachytherapy seeds, it is recommended to calculate the geometry function using more detailed methods instead of point and linear source approximations. This will provide more accurate results for other TG-43U1 dosimetry parameters such as radial dose function or anisotropy function which for some points are calculated via interpolation or extrapolation of the available discrete dosimetry data.

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A comparison of the basic photon and electron dosimetry data for Neptun 10PC linear accelerators

Shokrani P., Monadi S.

Nukleonika

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2008

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Vol. 53, No. 4

181-185

EN

. In recent years the similarity of dosimetric characteristics of modern linear accelerators with the same make, model and nominal energy, has become more common. The goal of this study was to quantitatively investigate the reproducibility of the basic photon and electron dosimetry data from Neptun 10PC accelerators across the institutions. In the current study, the photon and electron dosimetry data collected during acceptance and initial commissioning of six Neptun 10PC linear accelerators are analyzed. The dates of original installations of these six machines were evenly spread out over a 5 year period and the series of measurements were conducted during an average of 1-2 months after original installations. All units had identical energies and beam modifiers. For photon beams, the collected data include depth dose data, output factors and beam profile data in water. For electron beams, in addition to depth dose data and output factors, the effective source skin distance for 10 × 10 cm field size is also presented. For most beam parameters the variation (one standard deviation), was less than 1.0% (less than 2% for 2 parameters). A variation of this magnitude is expected to be observed during annual calibration of well-maintained accelerators. In conclusion, this study is presenting a consistent set of data for Neptun 10PC linear accelerators. This consistency implies that for this model, a standard data set of basic photon and electron dosimetry could be established, as a guide for future commissioning, beam modeling and quality assurance purposes.

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A study of the photoneutron dose equivalent resulting from a Saturne 20 medical linac using Monte Carlo method

Hashemi F., Hashemi-Malayeri B., Raisali G., Shokrani P., Sharafi A.

Nukleonika

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2007

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Vol. 52, nr 1

39-43

EN

High energy linacs have several advantages including lower skin dose and higher dose rate at deep sighted tumors. But, at higher energies photonuclear reactions produce neutron contamination. Photoneutron contamination has been investigated from the early days of modern linacs. However, more studies have become possible using Monte Carlo codes developed in recent years. The aim of this study was to investigate the photoneutron spectrum and dose equivalent produced by an 18 MV Saturne linac at different points of a treatment room and its maze. The MCNP4C code was used to simulate the transport of photoneutrons produced by a typical 18 MV Saturne linac. The treatment room of a radiotherapy facility in which a Saturne 20 linac is installed was modeled. Neutron dose equivalent was calculated and its variations at various distances from the center of the X-ray beam was studied. It was noted that by increasing the distance from the center of the beam, fast neutrons decrease rapidly, but thermal neutrons do not change significantly. In addition, the photoneutron dose equivalent was lower for smaller fields. The fast photoneutrons were not recorded in the maze. It can be concluded that the fast photoneutrons are highly attenuated by concrete barrier, while the slow photoneutrons are increased. In addition, increasing the X-ray field size increases the photoneutron dose equivalent around the treatment room and maze. It seems that the walls play an effective role in increasing the photoneutron dose equivalent.