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Bioactive surgical sutures

Zhukovsky V.

Autex Research Journal

2003

Vol. 3, no. 1

41--45

Investigations carried out into the development of bioactive surgical sutures and radioactive fibres are presented. Anti-microbial surgical sutures, which for a long period provide the wound with the antibiotics settled in their structure, can be of considerable use for precautions and treatment of surgical sepsis. Simultaneously the hydrolytic influence of proteolytic enzymes on the necrotising tissues, which serve as a nutrient medium for microbes, is desirable. The anaesthetic and anticancerous properties of sutures are also of such importance. Antibiotics (such as clindamycin, gentamycin, lincomycin etc.), proteolytic enzymes (such as tripsin and pepsin), anaesthetics (such as lidocaine, novocaine, trimecaine, and pyrocaine), and anti-tumour medicaments (such as prospydin, 5-fluorocyl, sarcolysin etc.) were fixed by us separately or in different combinations onto cation-exchanging polypropylene fibres with the help of ion-exchanging bonds. A principally new type of biologically active surgical fibres is radioactive fibres which exhibit their action by the emanation of ionising radiation from radioactive isotopes fixed in the fibres' structure. Sulphur-35 isotopes emanating soft beta-rays, and phosphorus-32 isotopes emanating much harder electrons were fixed by us onto polypropylene, polyethylene terephthalate, polyamide, and polyvinyl alcohol fibres by firm covalent bonds. Biological, medical and clinical tests showed the high effectiveness of the biological active sutures developed by us, as well as that of the radioactive surgical fibres used in different forms.

The development and manufacture of polymeric endoprosthetic meshes for the surgery of soft tissues

Zhukovsky V., Rovinskaya L., Vinokurova T., Zhukovskay I.

Autex Research Journal

2002

Vol. 2, no. 4

204--209

'Esfil' endoprosthetic meshes made of polypropylene monofilaments, 'Eslan' made of lavsan multifilaments and 'Ftorex' made of lavsan multifilaments with waterproofing fluoropolymer coating have been developed and manufactured for the plasty of soft supporting tissues after tumour resection and herniotomies, by damage to the abdominal wall and the diaphragm and in other surgical procedures. 'Esfil' polypropylene endoprostheses are biologically inert and resist the action of tissue fluids. The hydrophoby and solidity of the threads prevent the meshes from becoming infected. Prompt spreading of the fibroblasts along the filaments promotes the reparation of soft tissues. The 'Eslan' meshes are substantially softer and can be used when so-called 'gentle' implants are required. However, the capillarity of lavsan filaments may cause wound infections. The 'Ftorex' prostheses do not suffer from this disadvantage, due to impregnation of the pores between multifilaments with fluoropolymer. At the same time, the manipulation properties of the prostheses remain stable and their biocompatibility and bioresistance increase. Physico-mechanical, medical, biological and clinical tests allowed us to determine the optimal knitting structures of the endoprostheses we developed.